Phosphosulfonic acid-catalyzed green synthesis and bioassay of α-aryl-α′-1,3,4-thiadiazolyl aminophosphonates
Mohan Gundluru
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorSanthisudha Sarva
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorMadhu Kumar Reddy Kandula
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorVasudeva Reddy Netala
Department of Biotechnology, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorVijaya Tartte
Department of Botany, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorCorresponding Author
Suresh Reddy Cirandur
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Correspondence
Suresh Reddy Cirandur, Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Email: [email protected]
Search for more papers by this authorMohan Gundluru
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorSanthisudha Sarva
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorMadhu Kumar Reddy Kandula
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorVasudeva Reddy Netala
Department of Biotechnology, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorVijaya Tartte
Department of Botany, Sri Venkateswara University, Tirupati, India
Search for more papers by this authorCorresponding Author
Suresh Reddy Cirandur
Department of Chemistry, Sri Venkateswara University, Tirupati, India
Correspondence
Suresh Reddy Cirandur, Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Email: [email protected]
Search for more papers by this authorAbstract
A series of new α-aminophosphonates containing 1,3,4-thiadiazole moiety (4a–l) were synthesized via a simple, efficient, and one-pot three-component Kabachnik–Fields reaction of 2-amino-5-ethyl-1,3,4-thiadiazole with various aryl/heteroaryl aldehydes and diethylphosphite under solvent-free microwave irradiation conditions using phosphosulfonic acid, as a reusable and heterogeneous solid acid catalyst. All the title compounds were screened for radical scavenging activity by DPPH and H2O2 methods, and antimicrobial activity against bacteria (Gram-positive and Gram-negative) and fungi using the disc diffusion technique. They exhibited potent in vitro antioxidant and moderate antimicrobial activity.
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