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A Simple and Efficient Method for the Synthesis of Novel Pyrazolyl Isoxazoline Derivatives Using Hypervalent Iodine (III) Reagent
Rajesh Kumar,
Manoj Kumar,
Om Prakash,
Corresponding Author
Rajesh Kumar
Post Graduate Department of Chemistry, M. L. N. College, Yamuna Nagar, 135001 Haryana, India
Correspondence to: Rajesh Kumar; e-mail: [email protected] and Om Prakash; [email protected].Search for more papers by this authorManoj Kumar
Department of Chemistry, Kurukshetra University, Kurukshetra, 136 119 Haryana, India
Search for more papers by this authorCorresponding Author
Om Prakash
Department of Chemistry, Kurukshetra University, Kurukshetra, 136 119 Haryana, India
Correspondence to: Rajesh Kumar; e-mail: [email protected] and Om Prakash; [email protected].Search for more papers by this authorRajesh Kumar,
Manoj Kumar,
Om Prakash,
Corresponding Author
Rajesh Kumar
Post Graduate Department of Chemistry, M. L. N. College, Yamuna Nagar, 135001 Haryana, India
Correspondence to: Rajesh Kumar; e-mail: [email protected] and Om Prakash; [email protected].Search for more papers by this authorManoj Kumar
Department of Chemistry, Kurukshetra University, Kurukshetra, 136 119 Haryana, India
Search for more papers by this authorCorresponding Author
Om Prakash
Department of Chemistry, Kurukshetra University, Kurukshetra, 136 119 Haryana, India
Correspondence to: Rajesh Kumar; e-mail: [email protected] and Om Prakash; [email protected].Search for more papers by this authorContract grant sponsor: Department of Science and Technology (DST), New Delhi.
Contract grant number: SR/FT/CS-033/2010.
Abstract
A series of novel pyrazolyl isoxazolines were synthesized by 1,3-dipolar cycloaddition of pyrazolyl nitrile oxide with various activated alkene, such as acrylonitrile, methyl acrylate, and vinyl acetate, in the presence of iodobenzene diacetate in methanol containing a catalytic amount of TFA at room temperature (13 compounds upto 92% yield were isolated).
References
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