Synthesis of Novel Pyrimidine Derivatives Containing the Vinylsulfanyl Group by Regio- and Stereoselective Addition of Thiouracils to Ethynyl Ketones
Svetlana V. Amosova
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorTatyana I. Yaroshenko
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorLyudmila I. Larina
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorLyudmila V. Timokhina
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorCorresponding Author
Vladimir A. Potapov
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Correspondence to: Vladimir A. Potapov; e-mail: [email protected].Search for more papers by this authorSvetlana V. Amosova
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorTatyana I. Yaroshenko
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorLyudmila I. Larina
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorLyudmila V. Timokhina
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Search for more papers by this authorCorresponding Author
Vladimir A. Potapov
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, RUS-664033 Irkutsk, Russia
Correspondence to: Vladimir A. Potapov; e-mail: [email protected].Search for more papers by this authorABSTRACT
A regio- and stereoselective method for preparation of novel functionalized pyrimidine derivatives containing the vinylsulfanyl group has been developed based on addition reactions of 2-thiouracils with phenylethynyl ketones. Reactions with ketones containing the disubstituted triple bond afford adducts of Z-stereochemistry, whereas addition to ketone with the terminal triple bond gives preferentially products of E-configuration.
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