A novel and convenient method for synthesis of carbamoyl and thiocarbamoyl phosphonates
Corresponding Author
Babak Kaboudin
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, Iran
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, IranSearch for more papers by this authorHazegh Zahedi
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, Iran
Search for more papers by this authorCorresponding Author
Babak Kaboudin
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, Iran
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, IranSearch for more papers by this authorHazegh Zahedi
Department of Chemistry, Institute for Advanced Studies in Basic Sciences, Gava Zang, Zanjan 45195-1159, Iran
Search for more papers by this authorAbstract
A simple, efficient, and general method has been developed for the synthesis of carbamoyl and thiocarbamoyl phosphonic esters using CaCl2 as an efficient Lewis base catalyst. Carbamoyl and thiocarbamoyl phosphonic esters were obtained in good yield (37%–65%) and purity under mild conditions by the reaction of diethyl phosphite with isocyanates and isothiocyanates in the presence of CaCl2. This method is easy, rapid, and good-yielding reaction for the synthesis of carbamoyl and thiocarbamoyl phosphonic esters. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:250–253, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20538
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