Synthesis, characterization, and biological effects of diorganotin(IV) derivatives of substituted germyl propionic acid and crystal structure of 3-triphenylgermyl-3-P-fluorophenyl propionic acid
Corresponding Author
Muhammad Aziz Choudhary
Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad 13100, Pakistan
Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad 13100, PakistanSearch for more papers by this authorSumera Mahboob
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Search for more papers by this authorMohammad Mazhar
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Search for more papers by this authorSaqib Ali
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Search for more papers by this authorMasood Parvez
Department of Chemistry, The University of Calgary 2500, University Drive NW, Calgary T2N IN4, Alberta, Canada
Search for more papers by this authorXueqing Song
Department of Chemistry and Physics, University of the District of Columbia, Washington, DC 20008
Search for more papers by this authorGeorge Eng
Department of Chemistry and Physics, University of the District of Columbia, Washington, DC 20008
Search for more papers by this authorCorresponding Author
Muhammad Aziz Choudhary
Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad 13100, Pakistan
Department of Chemistry, University of Azad Jammu & Kashmir, Muzaffarabad 13100, PakistanSearch for more papers by this authorSumera Mahboob
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Search for more papers by this authorMohammad Mazhar
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Search for more papers by this authorSaqib Ali
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Search for more papers by this authorMasood Parvez
Department of Chemistry, The University of Calgary 2500, University Drive NW, Calgary T2N IN4, Alberta, Canada
Search for more papers by this authorXueqing Song
Department of Chemistry and Physics, University of the District of Columbia, Washington, DC 20008
Search for more papers by this authorGeorge Eng
Department of Chemistry and Physics, University of the District of Columbia, Washington, DC 20008
Search for more papers by this authorAbstract
A new series of diorganotin(IV) derivatives of the general formula (1R3GeCH2RCH2COO)2Sn3R2 has been prepared by the reaction of diorganotin chlorides/oxides with substituted germyl propionic acids in 1:2 mole ratios. These compounds have been characterized by elemental analyses and various spectroscopic techniques (IR, multinuclear NMR (1H, 13C, 119Sn), 119mSn Mössbauer spectroscopies and mass spectrometry). The single crystal structure of the precursor Ph3GeCHRFCH2COOH (RF = 4-FC6H4) has been determined by X-ray diffraction. Biological studies such as cytotoxicity, antibacterial, and cytotoxicity were also investigated. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:163–170, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20402
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