COVER ILLUSTRATION Evidence for short-term, motor learning-related structural plasticity in the adult human brain was revealed using diffusion MRI. Structural changes were detectable in cortical and sub-cortical brain regions of non-musicians after only 45 minutes of pianotraining. This work highlights the dynamic nature of of the adult human brain; and the use of diffusion MRI as a rapid and sensitive biomarker for gray-matter learning-driven plasticity.
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