MoCA in five Indian languages: A brief screening tool to diagnose dementia and MCI in a linguistically diverse setting
Subhash Kaul
Krishna Institute of Medical Sciences, Hyderabad, India
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Search for more papers by this authorCorresponding Author
Avanthi Paplikar
Department of Speech and Language Studies, Dr. S. R. Chandrasekhar Institute of Speech and Hearing, Bengaluru, India
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Correspondence
Avanthi Paplikar, Department of Speech and Language Studies, Dr. S. R. Chandrasekhar Institute of Speech and Hearing, Bengaluru, India.
Email: [email protected]
Search for more papers by this authorFeba Varghese
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorSuvarna Alladi
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorMeenakshi Sharma
Indian Council of Medical Research, New Delhi, India
Search for more papers by this authorR. S. Dhaliwal
Indian Council of Medical Research, New Delhi, India
Search for more papers by this authorSheetal Goyal
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorAralikatte Onkarappa Saroja
Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, India
Search for more papers by this authorFaheem Arshad
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorGollahalli Divyaraj
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Pause for Perspective, Hyderabad, India
Search for more papers by this authorAmitabha Ghosh
Apollo Gleneagles Hospital, Cognitive Neurology Unit, Kolkata, India
Search for more papers by this authorGowri K. Iyer
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Indian Institute of Public Health, Hyderabad, India
Search for more papers by this authorSunitha J
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorArfa Banu Khan
Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, India
Search for more papers by this authorRajmohan Kandukuri
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Search for more papers by this authorShailaja Mekala
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Search for more papers by this authorRamshekhar Menon
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorRanita Nandi
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorAshima Nehra
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorM. V. Padma
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorSubasree Ramakrishnan
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorLekha Sarath
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorManjari Tripathi
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorP. N. Sylaja
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorRavi Prasad Varma
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorMansi Verma
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorYeshaswini Vishwanath
Department of Psychology, Jyoti Nivas College, Bangalore, India
Search for more papers by this authorI. C. M. R-N. C. T. B Consortium
Search for more papers by this authorSubhash Kaul
Krishna Institute of Medical Sciences, Hyderabad, India
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Search for more papers by this authorCorresponding Author
Avanthi Paplikar
Department of Speech and Language Studies, Dr. S. R. Chandrasekhar Institute of Speech and Hearing, Bengaluru, India
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Correspondence
Avanthi Paplikar, Department of Speech and Language Studies, Dr. S. R. Chandrasekhar Institute of Speech and Hearing, Bengaluru, India.
Email: [email protected]
Search for more papers by this authorFeba Varghese
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorSuvarna Alladi
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorMeenakshi Sharma
Indian Council of Medical Research, New Delhi, India
Search for more papers by this authorR. S. Dhaliwal
Indian Council of Medical Research, New Delhi, India
Search for more papers by this authorSheetal Goyal
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorAralikatte Onkarappa Saroja
Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, India
Search for more papers by this authorFaheem Arshad
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorGollahalli Divyaraj
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Pause for Perspective, Hyderabad, India
Search for more papers by this authorAmitabha Ghosh
Apollo Gleneagles Hospital, Cognitive Neurology Unit, Kolkata, India
Search for more papers by this authorGowri K. Iyer
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Indian Institute of Public Health, Hyderabad, India
Search for more papers by this authorSunitha J
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorArfa Banu Khan
Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, India
Search for more papers by this authorRajmohan Kandukuri
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Search for more papers by this authorShailaja Mekala
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India
Search for more papers by this authorRamshekhar Menon
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorRanita Nandi
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorAshima Nehra
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorM. V. Padma
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorSubasree Ramakrishnan
Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India
Search for more papers by this authorLekha Sarath
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorManjari Tripathi
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorP. N. Sylaja
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorRavi Prasad Varma
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Search for more papers by this authorMansi Verma
All India Institute of Medical Sciences, Delhi, India
Search for more papers by this authorYeshaswini Vishwanath
Department of Psychology, Jyoti Nivas College, Bangalore, India
Search for more papers by this authorI. C. M. R-N. C. T. B Consortium
Search for more papers by this authorAbstract
Introduction and Objectives
Early dementia diagnosis in low and middle-income countries (LMIC) is challenging due to limited availability of brief, culturally appropriate, and psychometrically validated tests. Montreal Cognitive Assessment (MoCA) is one of the most widely used cognitive screening tests in primary and secondary care globally. In the current study, we adapted and validated MoCA in five Indian languages (Hindi, Bengali, Telugu, Kannada, and Malayalam) and determined the optimal cut-off points that correspond to screening for clinical diagnosis of dementia and MCI.
Methods
A systematic process of adaptation and modifications of MoCA was fulfilled. A total of 446 participants: 214 controls, 102 dementia, and 130 MCI were recruited across six centers.
Results
Across five languages, the area under the curve for diagnosis of dementia varied from 0.89 to 0.98 and MCI varied from 0.73 to 0.96. The sensitivity, specificity and optimum cut-off scores were established separately for five Indian languages.
Conclusions
The Indian adapted MoCA is standardized and validated in five Indian languages for early diagnosis of dementia and MCI in a linguistically and culturally diverse population.
CONFLICT OF INTEREST
The authors report no conflicts of interest.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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gps5808-sup-0001-suppl-data.docx22.6 KB | Supporting Information S1 |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Iracleous P, Nie JX, Tracy CS, et al. Primary care physicians' attitudes towards cognitive screening: findings from a national postal survey. Int J Geriatr Psychiatr. 2010; 25(1): 23-29.
- 2Cullen B, O’Neill B, Evans JJ, Coen RF, Lawlor BA. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatr. 2007; 78(8): 790-799. https://doi.org/10.1136/jnnp.2006.095414
- 3Ismail Z, Rajji TK, Shulman KI. Brief cognitive screening instruments: an update. Int J Geriatr Psychiatr A j psychiatr late life allied sci. 2010; 25(2): 111-120. https://doi.org/10.1002/gps.2306
- 4Prince MJ, Wimo A, Guerchet MM, Ali GC, Wu YT, Prina M. World Alzheimer Report 2015-The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends; 2015.
- 5Forlenza OV, Diniz BS, Gattaz WF. Diagnosis and biomarkers of predementia in Alzheimer's disease. BMC Med. 2010; 8(1): 1-14. https://doi.org/10.1186/1741-7015-8-89
- 6Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999; 56(3): 303-308. https://doi.org/10.1001/archneur.56.3.303
- 7Bruscoli M, Lovestone S. Is MCI really just early dementia? A systematic review of conversion studies. Int Psychogeriatr. 2004; 16(2): 129-140. https://doi.org/10.1017/s1041610204000092
- 8Rosli R, Tan MP, Gray WK, Subramanian P, Chin AV. Cognitive assessment tools in Asia: a systematic review. Int Psychogeriatr. 2016; 28(2): 189-210. https://doi.org/10.1017/s1041610215001635
- 9Folstein MF, Folstein SE, McHugh PR. Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3): 189-198. https://doi.org/10.1016/0022-3956(75)90026-6
- 10Mathuranath PS, Cherian JP, Mathew R, George A, Alexander A, Sarma SP. Mini mental state examination and the Addenbrooke's cognitive examination: effect of education and norms for a multicultural population. Neurol India. 2007; 55(2):106. https://doi.org/10.4103/0028-3886.32779
- 11Swati B, Sreenivas V, Manjari T, Ashima N. Dementia assessment by Rapid test (DART): an Indian screening tool for dementia. J Alzheimers Dis Parkinsonism. 2015; 5(198). https://doi.org/10.4172/2161-0460.1000198
- 12Yang DW, Chey JY, Kim SY, Kim BS. The development and validation of Korean dementia screening questionnaire (KDSQ). J Korean Neurol Assoc. 2002; 20(2): 135-141.
- 13Sharma DA, Chaudhary P, Sheth M, Dalal D. Translation, cultural adaptation and validation of ACE III for assessment of cognition for Gujarati population. J Clin Diagn Res. 2018; 12(6).
- 14 MoCA - Cognitive assessment. MoCA–Cognitive Assessment; 2021. https://www.mocatest.org/reference/
- 15Davis DH, Creavin ST, Noel-Storr A, et al. Neuropsychological tests for the diagnosis of Alzheimer’s disease dementia and other dementias: a generic protocol for cross-sectional and delayed-verification studies. Cochrane database Syst Rev. 2013;(3). https://doi.org/10.1002/14651858.cd010460
10.1002/14651858.cd010460 Google Scholar
- 16Gupta M, Gupta V, Buckshee RN, Sharma V. Validity and reliability of Hindi translated version of Montreal cognitive assessment in older adults. Asian J Psychiat. 2019; 45: 125-128. https://doi.org/10.1016/j.ajp.2019.09.022
- 17Krishnan S, Justus S, Meluveettil R, Menon RN, Sarma SP, Kishore A. Validity of Montreal Cognitive Assessment in non-English speaking patients with Parkinson's disease. Neurol India. 2015; 63(1):63. https://doi.org/10.4103/0028-3886.152637
- 18India P. Census of India 2011 Provisional Population Totals. Office of the Registrar General and Census Commissioner; 2011.
- 19Nasreddine ZS, Phillips NA, Bédirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005; 53(4): 695-699. https://doi.org/10.1111/j.1532-5415.2005.53221.x
- 20Guillemin F, Bombardier C, Beaton D. Cross-cultural adaptation of health-related quality of life measures: literature review and proposed guidelines. J Clin Epidemiol. 1993; 46(12): 1417-1432. https://doi.org/10.1016/0895-4356(93)90142-n
- 21Alladi S, Shailaja M, Mridula KR, et al. Mild cognitive impairment: clinical and imaging profile in a memory clinic setting in India. Dementia geriatric cognitive Disord. 2014; 37(1-2): 113-124. https://doi.org/10.1159/000354955
- 22Mathuranath PS, Hodges JR, Mathew R, Cherian PJ, George A, Bak TH. Adaptation of the ACE for a Malayalam speaking population in southern India. Int J Geriatr Psychiatr. 2004; 19(12): 1188-1194. https://doi.org/10.1002/gps.1239
- 23Mekala S, Paplikar A, Mioshi E, et al. Dementia diagnosis in seven languages: the Addenbrooke’s Cognitive Examination-III in India. Arc Clin Neuropsychol. 2020; 35(5): 528-538. https://doi.org/10.1093/arclin/acaa013
- 24Morris JC. Clinical dementia rating: a reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. Int Psychogeriatr. 1997; 9(S1): 173-176. https://doi.org/10.1017/s1041610297004870
- 25Rao SL, Subbakrishna D, Gopukumar K. NIMHANS Neuropsychology Battery-2004, Manual. National Institute of Mental Health and Neurosciences; 2004.
- 26Iyer GK, Paplikar A, Alladi S, et al. Standardising dementia diagnosis across linguistic and educational diversity: study design of the indian council of medical research-neurocognitive tool box (ICMR-NCTB). J Int Neuropsychol Soc. 2020; 26(2): 172-186. https://doi.org/10.1017/s1355617719001127
- 27Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004; 256(3): 183-194. https://doi.org/10.1111/j.1365-2796.2004.01388.x
- 28Menon RN, Varghese F, Paplikar A, et al. Validation of Indian council of medical research neurocognitive tool box in diagnosis of mild cognitive impairment in India: lessons from a harmonization process in a linguistically diverse society. Dementia Geriatric Cognitive Disord. 2020; 49(4): 355-364. https://doi.org/10.1159/000512393
- 29Stein DJ, Phillips KA, Bolton D, Fulford KWM, Sadler JZ, Kendler KS. What is a mental/psychiatric disorder? From DSM-IV to DSM-V. Psychol Med. 2010; 40(11): 1759-1765. https://doi.org/10.1017/s0033291709992261
- 30Verma M, Tripathi M, Nehra A, et al. Validation of ICMR neurocognitive toolbox for dementia in the linguistically diverse context of India. Front Neurol. 2021; 12:1828. https://doi.org/10.3389/fneur.2021.661269
- 31McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's dementia. 2011; 7(3): 263-269. https://doi.org/10.1016/j.jalz.2011.03.005
- 32Román GC, Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology. 1993; 43(2):250. https://doi.org/10.1212/wnl.43.2.250
- 33Rascovsky K, Hodges JR, Knopman D, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain. 2011; 134(9): 2456-2477. https://doi.org/10.1093/brain/awr179
- 34McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005; 65(12): 1863-1872. https://doi.org/10.1212/01.wnl.0000187889.17253.b1
- 35Vasanta D, Suvarna A, Sireesha J, Raju SB. Language choice and language use patterns among Telugu-Hindi/Urdu-English speakers in Hyderabad, India. In: Proceedings of the International Conference on Language, Society and Culture in Asian Contexts. Mahasarakam University; 2010: 57-67.
- 36Memória CM, Yassuda MS, Nakano EY, Forlenza OV. Brief screening for mild cognitive impairment: validation of the Brazilian version of the Montreal cognitive assessment. Int J Geriatr Psychiatr. 2013; 28(1): 34-40. https://doi.org/10.1002/gps.3787
- 37Costa AS, Fimm B, Friesen P, et al. Alternate-form reliability of the Montreal cognitive assessment screening test in a clinical setting. Dementia geriatric cognitive Disord. 2012; 33(6): 379-384. https://doi.org/10.1159/000340006
- 38Lu J, Li D, Li F, et al. Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study. J Geriatr Psychiatr Neurol. 2011; 24(4): 184-190. https://doi.org/10.1177/0891988711422528
- 39Freitas S, Simões MR, Alves L, Santana I. Montreal cognitive assessment (MoCA): normative study for the Portuguese population. J Clin Exp Neuropsychol. 2011; 33(9): 989-996. https://doi.org/10.1080/13803395.2011.589374
- 40Fujiwara Y, Suzuki H, Yasunaga M, et al. Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment. Geriatrics gerontol Int. 2010; 10(3): 225-232. https://doi.org/10.1111/j.1447-0594.2010.00585.x
- 41Lee JY, Lee DW, Cho SJ, et al. Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment. J Geriatr Psychiatr Neurol. 2008; 21(2): 104-110. https://doi.org/10.1177/0891988708316855
- 42Tsai CF, Lee WJ, Wang SJ, Shia BC, Nasreddine Z, Fuh JL. Psychometrics of the Montreal Cognitive Assessment (MoCA) and its subscales: validation of the Taiwanese version of the MoCA and an item response theory analysis. Int Psychogeriatr. 2012; 24(4): 651-658. https://doi.org/10.1017/s1041610211002298
- 43Gil L, Ruiz de Sánchez C, Gil F, Romero SJ, Pretelt Burgos F. Validation of the Montreal Cognitive Assessment (MoCA) in Spanish as a screening tool for mild cognitive impairment and mild dementia in patients over 65 years old in Bogotá, Colombia. Int J Geriatr Psychiatr. 2015; 30(6): 655-662. https://doi.org/10.1002/gps.4199
- 44Freud T, Vostrikov A, Dwolatzky T, Punchik B, Press Y. Validation of the Russian version of the MoCA test as a cognitive screening instrument in cognitively asymptomatic older individuals and those with mild cognitive impairment. Front Med. 2020; 7:447. https://doi.org/10.3389/fmed.2020.00447
- 45Yeung PY, Wong LL, Chan CC, Leung JL, Yung CY. A validation study of the Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) in Chinese older adults in Hong Kong. Hong Kong Med J. 2014; 20(6): 504-510. https://doi.org/10.12809/hkmj144219
- 46Din NC, Shahar S, Zulkifli BH, Razali R, Vyrn CA, Omar A. Validation and optimal cut-off scores of the bahasa Malaysia version of the montreal cognitive assessment (MoCA-BM) for mild cognitive impairment among community dwelling older adults in Malaysia. Sains Malays. 2016; 45(9): 1337-1343.
- 47Zhou SA, Zhu J, Zhang N, et al. The influence of education on Chinese version of Montreal cognitive assessment in detecting amnesic mild cognitive impairment among older people in a Beijing rural community. Sci World J. 2014: 1-7. https://doi.org/10.1155/2014/689456
- 48Muñoz-Neira C, Henríquez Chaparro F, Delgado C, Brown J, Slachevsky A. Test Your Memory—Spanish version (TYM-S): a validation study of a self-administered cognitive screening test. Int J Geriatr Psychiatr. 2014; 29(7): 730-740. https://doi.org/10.1002/gps.4055
- 49Lifshitz M, Dwolatzky T, Press Y. Validation of the Hebrew version of the MoCA test as a screening instrument for the early detection of mild cognitive impairment in elderly individuals. J Geriatr Psychiatr Neurol. 2012; 25(3): 155-161. https://doi.org/10.1177/0891988712457047
- 50Wang BR, Zheng HF, Xu C, Sun Y, Zhang YD, Shi JQ. Comparative diagnostic accuracy of ACE-III and MoCA for detecting mild cognitive impairment. Neuropsychiatr Dis Treat. 2019; 15: 2647-2653. https://doi.org/10.2147/ndt.s212328
- 51Matias-Guiu JA, Fernández de Bobadilla R, Escudero G, et al. Validation of the Spanish version of Addenbrooke’s Cognitive Examination III for diagnosing dementia. Neurol. 2015; 30(9): 545-551. English Ed. https://doi.org/10.1016/j.nrleng.2014.05.001
- 52Sherwin BB. Mild cognitive impairment: potential pharmacological treatment options. J Am Geriatr Soc. 2000; 48(4): 431-441. https://doi.org/10.1111/j.1532-5415.2000.tb04703.x