The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study
Corresponding Author
L. Wouts
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.Search for more papers by this authorJ.G. Janzing
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Search for more papers by this authorI.K. Lampe
Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
Search for more papers by this authorB. Franke
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
On behalf of the Nijmegen Biomedical Study principal investigators.
Search for more papers by this authorF. de Vegt
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
On behalf of the Nijmegen Biomedical Study principal investigators.
Search for more papers by this authorI. Tendolkar
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
Search for more papers by this authorM.B. van Iersel
Department of Geriatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Search for more papers by this authorJ.K. Buitelaar
Department of Cognitive Neuroscience, NCEBP, Nijmegen
Search for more papers by this authorR.C. Oude Voshaar
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Search for more papers by this authorCorresponding Author
L. Wouts
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.Search for more papers by this authorJ.G. Janzing
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Search for more papers by this authorI.K. Lampe
Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
Search for more papers by this authorB. Franke
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
On behalf of the Nijmegen Biomedical Study principal investigators.
Search for more papers by this authorF. de Vegt
Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
On behalf of the Nijmegen Biomedical Study principal investigators.
Search for more papers by this authorI. Tendolkar
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
Search for more papers by this authorM.B. van Iersel
Department of Geriatrics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Search for more papers by this authorJ.K. Buitelaar
Department of Cognitive Neuroscience, NCEBP, Nijmegen
Search for more papers by this authorR.C. Oude Voshaar
Department of Psychiatry (961), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Search for more papers by this authorAbstract
Objective
Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life.
Methods
Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into four levels: none, ≥2 vascular risk factors, cardiac disease or stroke.
Results
Neuroticism was strongly associated with CRDS in women (OR: 1.6, 95% CI: 1.4–1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism: OR: 0.8, 95% CI: 0.6–0.9; stroke by neuroticism: OR: 0.8, 95% CI: 0.6–0.96) when predicting CRDS.
Conclusions
In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease. Copyright © 2010 John Wiley & Sons, Ltd.
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