Volume 10, Issue 6 pp. 545-549
Genetic Analysis of Multiple Quantitative Risk Factors for Complex Disease
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LISREL modeling of high density lipoprotein cholesterol (HDL) levels in male twins

Dr. Joseph E. Schwartz

Corresponding Author

Dr. Joseph E. Schwartz

State University of New York at Stony Brook, Stony Brook, New York

State University of New York at Stony Brook, Stony Brook, NY 11794-8790Search for more papers by this author
Huixing Yuan

Huixing Yuan

State University of New York at Stony Brook, Stony Brook, New York

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Nancy R. Mendell

Nancy R. Mendell

State University of New York at Stony Brook, Stony Brook, New York

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Stephen J. Finch

Stephen J. Finch

State University of New York at Stony Brook, Stony Brook, New York

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Abstract

Based on the LISREL modeling approach for data from monozygotic (MZ) and dizygotic (DZ) twins [Heath et al., 1989; Neale and Cardon, 1992], the hypothesized variance of the logarithm of high density lipoprotein cholesterol due to additive genetic factors was estimated to equal 19% for males. Unobserved common environment accounted for 32% of the variance of log HDL. Both estimates controlled for body mass, alcohol consumption, and smoking. The model had very strong goodness-of-fit indices. © 1993 Wiley-Liss, Inc.

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