Volume 10, Issue 6 pp. 477-482
Genetic Analysis of Disorders with Apparent Heterogeneity
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A novel polylocus method for linkage analysis using the lod-score or affected sib-pair method

Dr. Joseph D. Terwilliger

Corresponding Author

Dr. Joseph D. Terwilliger

Department of Genetics and Development, Columbia University, New York

722 West 168th Street, Columbia University, Unit 58, New York, NY 10032Search for more papers by this author
Jurg Ott

Jurg Ott

Department of Genetics and Development, Columbia University, New York

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First published: 1993
Citations: 31

Abstract

A novel approach to combining data from multiple linked loci is proposed that can provide substantial increases in power over normal two-point linkage analysis or sib-pair analysis, with a substantial saving in computing time over traditional multipoint methods. © 1993 Wiley-Liss, Inc.

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