Linkage of Alzheimer's disease to chromosome 21 and chromosome 19 markers: Effect of age of onset assumptions

Corresponding Author

Dr. L. R. Goldin

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland

Clinical Neurogenetics Branch, NIMH, 9000 Rockville Pike, Building 10 3N218, Bethesda, MD 20892Search for more papers by this author

E. S. Gershon,

E. S. Gershon

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland

Search for more papers by this author

Dr. L. R. Goldin,

Corresponding Author

Dr. L. R. Goldin

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland

Clinical Neurogenetics Branch, NIMH, 9000 Rockville Pike, Building 10 3N218, Bethesda, MD 20892Search for more papers by this author

E. S. Gershon,

E. S. Gershon

Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland

Search for more papers by this author

First published: 1993

https://doi.org/10.1002/gepi.1370100620

Citations: 3

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Abstract

Age of onset heterogeneity in Alzheimer's disease families was modelled by allowing for different liability classes for affected individuals according to their age of onset when calculating lod scores to chromosome 21 and chromosome 19 markers. Linkage to chromosome 21 was supported in the Boston data set, and the method of age correction did not greatly change the lod scores when only affected individuals were analyzed. The location of a gene on chromosome 19 for late age of onset illness was affected by the assumptions about early onset individuals. © 1993 Wiley-Liss, Inc.

1 This article is a US Government work and, as such, is in the public domain in the United States of America.

References

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Volume10, Issue6

1993

Pages 449-454

Linkage of Alzheimer's disease to chromosome 21 and chromosome 19 markers: Effect of age of onset assumptions

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Linkage of Alzheimer's disease to chromosome 21 and chromosome 19 markers: Effect of age of onset assumptions

Abstract

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