Genetic Analysis of Disorders with Apparent Heterogeneity

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The impact of some parameters on linkage analysis of Alzheimer's disease

Corresponding Author

Dr. J. F. Xu

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

P.O. Box 396, Department of Epidemiology, School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD 21205Search for more papers by this author

E. W. Taylor,

E. W. Taylor

School of Medicine, The Johns Hopkins University, Baltimore, Maryland

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F. W. Lung,

F. W. Lung

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

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A. S. Chung,

A. S. Chung

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

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G. A. Chase,

G. A. Chase

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

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N. E. Maestri,

N. E. Maestri

School of Medicine, The Johns Hopkins University, Baltimore, Maryland

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D. A. Meyers,

D. A. Meyers

School of Medicine, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

Dr. J. F. Xu,

Corresponding Author

Dr. J. F. Xu

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

P.O. Box 396, Department of Epidemiology, School of Hygiene and Public Health, 615 N. Wolfe Street, Baltimore, MD 21205Search for more papers by this author

E. W. Taylor,

E. W. Taylor

School of Medicine, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

F. W. Lung,

F. W. Lung

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

A. S. Chung,

A. S. Chung

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

G. A. Chase,

G. A. Chase

School of Hygiene, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

N. E. Maestri,

N. E. Maestri

School of Medicine, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

D. A. Meyers,

D. A. Meyers

School of Medicine, The Johns Hopkins University, Baltimore, Maryland

Search for more papers by this author

First published: 1993

https://doi.org/10.1002/gepi.1370100613

Citations: 4

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Abstract

The two-point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age-dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage. © 1993 Wiley-Liss, Inc.

References

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Citing Literature

Volume10, Issue6

1993

Pages 407-412

The impact of some parameters on linkage analysis of Alzheimer's disease

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The impact of some parameters on linkage analysis of Alzheimer's disease

Abstract

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