Genetic Analysis of Disorders with Apparent Heterogeneity
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Genetic analysis of Alzheimer's disease: A summary of contributions to GAW8
Dr. Ellen M. Wijsman,
Corresponding Author
Dr. Ellen M. Wijsman
Division of Medical Genetics, RG-25, and Department of Biostatistics, University of Washington, Seattle, Washington
Medical Genetics, RG-25, University of Washington, Seattle, WA 98195Search for more papers by this authorDr. Ellen M. Wijsman,
Corresponding Author
Dr. Ellen M. Wijsman
Division of Medical Genetics, RG-25, and Department of Biostatistics, University of Washington, Seattle, Washington
Medical Genetics, RG-25, University of Washington, Seattle, WA 98195Search for more papers by this authorAbstract
Participants in the Alzheimer's disease component of GAW8 had access to three collections of pedigrees, complete with marker data from chromosomes 19 and 21. There were a total of 94 independent pedigrees and more than 2,000 individuals. Onset of the disorder varied widely among pedigrees. These data are briefly summarized along with a discussion of the problems associated with performing genetic analyses of Alzheimer's disease. The majority of the workshop participants performed an analysis either with some of the data contributed to the workshop or with data simulated on pedigrees of the same structure and disease status as were contributed. There were also a few purely methodological contributions. The contributions are summarized in three general areas: family association and phenotype, linkage analysis, and heterogeneity tests. © 1993 Wiley-Liss, Inc.
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