The t(II; 22)(pI5.5; qII.23) in a retroperitoneal rhabdoid tumor also includes a regional deletion distal to CRYBB2 on 22q
Corinne Besnard-Guérin
Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, California
Search for more papers by this authorCorresponding Author
Webster Cavenee
Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, California
Department of Medicine, University of California-San Diego, La Jolla, California
Center for Molecular Genetics, University of California-San Diego, La Jolla, California
Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093-0660, U.S.A.Search for more papers by this authorIrene Newshams
Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, California
Department of Medicine, University of California-San Diego, La Jolla, California
Search for more papers by this authorCorinne Besnard-Guérin
Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, California
Search for more papers by this authorCorresponding Author
Webster Cavenee
Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, California
Department of Medicine, University of California-San Diego, La Jolla, California
Center for Molecular Genetics, University of California-San Diego, La Jolla, California
Ludwig Institute for Cancer Research, 9500 Gilman Drive, La Jolla, CA 92093-0660, U.S.A.Search for more papers by this authorIrene Newshams
Ludwig Institute for Cancer Research, University of California-San Diego, La Jolla, California
Department of Medicine, University of California-San Diego, La Jolla, California
Search for more papers by this authorAbstract
Translocations and deletions involving chromosomal band 22q 11 are common genetic aberrations in malignant rhabdoid tumors. Previous molecular analyses of a t(11; 22) in the malignant rhabdoid tumor cell line TM87-16 localized the breakpoint distal to BCR on 22q 11. In the present report, we have further refined the map position of this breakpoint between CRYBB2 and D22S258. Moreover, the D22S258, CRYBA4, D22S300, D22SI, and D22S310 loci, which lie between CRYBB2 and D22S42, were found to be deleted, presumably as a result of the translocation event. The identification of this deletion of at least 2 Mb on the long arm of chromosome 22 should be helpful for mapping the gene(s) in the region involved in the development of malignant rhabdoid tumors as well as providing insights into the mechanisms of chromosomal translocation in human solid tumors.
References
- Aarts HJ, Den Dunnen JT, Lubsen NH, Schoenmakers JG (1987) Linkage between the beta B2 and beta B3 crystallin genes in man and rat: A remnant of an ancient beta-crystallin gene cluster. Gene 59: 127–135.
- Aurias A, Rimbaut C, Buffe D, Dubousset J, Mazabraud A (1983) Translocation of chromosome 22 in Ewing's sarcoma. CR Acad Sci 296: 1105–1107.
- Barker D, Schafer M, White R (1984) Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell 36: 131–138.
- Biegel JA, Rorke LB, Packer RJ, Emanuel BS (1990) Monosomy 22 in rhabdoid or atypical tumors of the brain. J Neurosurg 73: 710–714.
- Biegel JA, Burk CD, Parmiter AH, Emanuel BS (1992) Molecular analysis of a partial deletion of 22q in a central nervous system rhabdoid tumor. Genes Chromosom Cancer 5: 104–108.
- Biggs PJ, Garen PD, Powers JM, Garvin AJ (1987) Malignant rhabdoid tumor of the central nervous system. Hum Pathol 18: 332–337.
- Bijlsma EK, Delattre O, Juyn JA, Melot T, Westerveld A, Dumanski JP, Thomas G, Hulsebos TJ (1993) Regional fine mapping of the beta crystallin genes on chromosome 22 excludes these genes as physically linked markers for neurofibromatosis type 2. Genes Chromosom Cancer 8: 112–118.
- Budarf M, Canaani E, Emanuel BS (1988) Linear order of the four BCR-related loci in 22q11. Genomics 3: 168–171.
- Buetow KH, Duggan D, Yang B, Ludwigsen S, Puck J, Porter J, Budarf M, Spielman R, Emanuel BS (1993) A microsatellite based multipoint index map of human chromosome 22. Genomics 18: 329–339.
- Buetow KH, Weber JL, Ludwigsen S, Scherpbier-Heddema T, Duyk GM, Sheffield VC, Wang Z, Murray JC (1994) Integrated human genome-wide maps constructed using the ceph reference panel. Nature Genet 6: 391–393.
- Collins JE, Everett LA, Bentley DR, Dunham I (1992) A panel of human chromosome 22-specific sequence tagged sites. Genomics 14: 1098–1103.
- Croce CM, Huebner K, Isobe M, Fainstain E, Lifshitz B, Shtivelman E, Canaani E (1987) Mapping of four distinct BCR-related loci to chromosome region 22q11: Order of BCR loci relative to chronic myelogenous leukemia and acute lymphoblastic leukemia breakpoints. Proc Natl Acad Sci USA 84: 7174–7178.
- Delattre O, Azambuja CJ, Aurias A, Zucman J, Peter M, Zhang F, Hors-Cayla MC, Rouleau G, Thomas G (1991) Mapping of human chromosome 22 with a panel of somatic cell hybrids. Genomics 9: 721–727.
- Douglass EC, Valentine M, Rowe ST, Parham DM, Wilimas J, Sanders JM, Houghton PJ (1990) Malignant rhabdoid tumor: A highly malignant childhood tumor with minimal karyotypic changes. Genes Chromosom Cancer 2: 210–216.
- Driscoll DA, Budarf ML, Emanuel BS (1992) A genetic etiology for DiGeorge syndrome: Consistent deletions and microdeletions of 22q11. Am J Hum Genet 50: 924–933.
- Dumanski JP, Carlbom E, Collins VP, Nordenskjold M (1987) Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 84: 9275–9279.
- Dumanski JP, Carlbom E, Collins VP, Nordenskjold M, Emanuel BS, Budarf ML, McDermid HE, Wolff R, O'Connell P, White R, Lalouel JM, Leppert M (1991) A map of 22 loci on human chromosome 22. Genomics 11: 709–719.
- Ekfors TO, Aho HJ, Kekomaki M (1985) Malignant rhabdoid tumor of the prostatic region. Immunohistological and ultrastructural evidence for epithelial origin. Virchows Arch (A) 406: 381–388.
- Feinberg AP, Vogelstein B (1984) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Ann Biochem 137: 266–267.
- Gao LM, Goldman J (1991) Long-range mapping of the normal BCR gene. Leukemia 5: 555–560.
- Haas JE, Palmer N, Weinberg AJ, Beckwith JB (1981) Ultra structure of malignant rhabdoid tumor of the kidney. A distinctive renal tumor of children. Hum Pathol 12: 646–657.
- Hulsebos TJ, Bijlsma EK, Geurts van Kessel AH, Brakenhoff RH, Westerveld A (1991) Direct assignment of the human beta B2 and beta B3 crystallin genes to 22q11.2-q12: Markers for neurofibromatosis 2. Cytogenet Cell Genet 56: 171–175.
- Karnes PS, Tran TN, Cui MY, Bogenmann E, Shimada H, Ying KL (1991) Establishment of a rhabdoid tumor cell line with a specific chromosomal abnormality, 46,XY,t(11; 22)(p15.5; q11.23). Cancer Genet Cytogenet 56: 31–38.
- Lemos LB, Hamoudi AB (1978) Malignant thymic tumor in an infant (malignant histiocytoma). Arch Pathol Lab Med 102: 84–89.
- MacCollin M, Romano D, Budarf M, Denny C, Trofatter J, Menon A, Rouleau G, Fontaine B, Emanuel B, Gusella J (1993) A set of STS assays targeting the chromosome 22 physical framework markers. Genomics 15: 680–683.
- McDermid HE, Budarf M, Emanuel BS (1993) Long-range restriction map of human chromosome 22q11–22q12 between the lambda immunoglobulin locus and the Ewing sarcoma breakpoint. Genomics 18: 308–318.
- Newsham I, Daub D, Besnard-Guerin C, Cavenee W (1994) Molecular sublocalization and characterization of the 11; 22 translocation breakpoint in a malignant rhabdoid tumor. Genomics 19: 433–440.
-
Ota S,
Crabbe DC,
Tran TN,
Triche TJ,
Shimada H
(1993)
Malignant rhabdoid tumor. A study with two established cell lines.
Cancer
71:
2862–2872.
10.1002/1097-0142(19930501)71:9<2862::AID-CNCR2820710930>3.0.CO;2-D CAS PubMed Web of Science® Google Scholar
- Palmer NF, Sutow W (1983) Clinical aspect of the rhabdoid tumor of the kidney: A report of the National Wilms' Tumor Study Group. Med Pediatr Oncol 11: 242–245.
- Parham DM, Peiper SC, Robicheaux G, Ribeiro RC, Douglass EC (1988) Malignant rhabdoid tumor of the liver. Evidence for epithelial differentiation. Arch Pathol Lab Med 112: 61–64.
- Rouleau GA, Haines JL, Bazanowski A, Colella-Crowley A, Trofatter JA, Wexler NS, Conneally PM, Gusella JF (1989) A genetic linkage map of the long arm of human chromosome 22. Genomics 4: 1–6.
- Seizinger BR, Tanzi RE, Gilliam T C, Bader JL, Parry DM, Spence MA, Marazita ML Gibbons K, Hobbs W, Gusella JF (1986) Genetic linkage analysis of neurofibromatosis with DNA markers. Ann NY Acad Sci 486: 304–310.
- Shashi V, Lovell Ma, Vonkapherr C, Waldron P, Golden WL (1994) Malignant rhabdoid tumor of the kidney-Involvement of chromosome 22. Genes Chromosom Cancer 10: 49–54.
-
Small EJ,
Gordon GJ,
Dahms BB
(1985)
Malignant rhabdoid tumor of the heart in an infant.
Cancer
55:
2850–2853.
10.1002/1097-0142(19850615)55:12<2850::AID-CNCR2820551224>3.0.CO;2-U CAS PubMed Web of Science® Google Scholar
- ten Hoeve J, Morris C, Poustka A, Groffen J, Heisterkamp N (1993) Isolation of NotI sites from chromosome 22q11. Genomics 18: 588–597.
- Turc-Carel C, Philip I, Berger MP, Philip T, Lenoir G (1983) Chromosomal translocation (11; 22) in cell lines of Ewing's sarcoma. CR Acad Sci 296: 1101–1103.
- van Rens GL, Geurts van Kessel AH, Bloemendal H (1992) Localization of the beta A4-crystallin gene (CRYBA4) on human chromosome 22 in the region q11.2–q13.1. Cytogenet Cell Genet 61: 180–183.
- Yang AH, Chen WY, Chiang H (1994) Malignant rhabdoid tumour of colon. Histopathology 24: 89–91.
- Zang KD (1982) Cytological and cytogenetical studies on human meningioma. Cancer Genet Cytogenet 6: 249–274.
