Environmental mutagenesis: Past and future directions
Corresponding Author
James T. Macgregor
SRI International, Menlo Park, California
SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025Search for more papers by this authorCorresponding Author
James T. Macgregor
SRI International, Menlo Park, California
SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025Search for more papers by this authorAbstract
On the occasion of the 25th anniversary of the Environmental Mutagen Society, this article presents a personal reflection on the development of environmental mutagenesis as a unique scientific discipline. The events following the demonstration of chemical mutagenesis in the 1940s and leading to the formation of the Environmental Mutagen Society in 1969 are reviewed. Scientific progress and regulatory practices in the field of environmental mutagenesis during the twenty-five years since the founding of the Society are discussed, and speculation on the likely future of the field is presented.
References
- Ames BN, Durston WE, Yamasaki E, Lee FD (1973): Carcinogens are mutagens: A simple test system incorporating liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 70: 2281–2285.
- Arber W (1974): DNA modification and restriction. Prog Nucleic Acid Res Mol Biol 14: 1–37.
- Auerbach C, Robson JM (1946): Chemical production of mutations. Nature 157: 302.
- Avery OT, McLeod CM, McCarty M (1944): Studies on the chemical nature of the substance inducing transformation of Pneumococcal types. J Exp Med 79: 137–158.
- Cohen SN (1975): The manipulation of genes. Sci Am 233: 25–33.
- Cohen SN (1976): Gene manipulation. N Engl J Med 294: 883–889.
- Crespi CL, Langenbach R, Penman BW (1993): Human cell lines, derived from AHH-1 TK+/- human lymphoblasts, genetically engineered for expression of cytochromes P450. Toxicology 82: 89–104.
- Devary Y, Gottlieb RA, Lau LF, Karin M (1991): Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol Cell Biol 11: 2804–2811.
- Eastmond DA, Rupa DS, Chen HW, Hasegawa L (1993): Multicolor fluorescence in situ hybridization to detect aneuploidy and chromosome breakage in interphase cells and micronuclei. Abstract 6th Int Conf Environ Mutagens. Melbourne, Australia, February 21-26, p 64.
- Fabry ME (1993): Transgenic animal models of sickle cell disease. Experientia 49: 28–36.
- Fiddes JC (1977): The nucleotide sequence of a viral DNA. Sci Am 237: 54–67.
- Fornace AJ Jr, Jackman J, Hollander MC, Hoffman-Liebermann B, Liebermann DA (1992): Genotoxic-stress-response genes and growth-arrest genes. Ann NY Acad Sci 663: 139–153.
- Hanahan D (1989): Transgenic mice as probes into complex systems. Science 246: 1265–1275.
- Herrlich P, Angel P, Rahmsdorf JH (1986): The mammalian genetic stress response. Adv Enzyme Regul 25: 485–504.
- Holbrook NJ, Fornace AJ Jr (1991): Response to adversity: Molecular control of gene activation following genotoxic stress. The New Biologist 3: 825–833.
- Iyer VN, Szybalski W (1958): Two simple methods for the detection of chemical mutagens. Appl Microbiol 6: 23–29.
- MacGregor JT, Wehr CM, Henika PR, Shelby MD (1990): The in vivo erythrocyte micronucleus test: Measurement at steady state increases assay efficiency and permits integration with toxicity studies. Fundam Appl Toxicol 14: 513–522.
- Mailing HV (1971): Dimethylnitrosamine: Formation of mutagenic compounds by interaction with mouse liver microsomes. Mutat Res 13: 425–429.
- McCann J, Choi E, Yamasaki E, Ames BN (1975): Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc Natl Acad Sci USA 72: 5135–5139.
- Miller EC, Miller JA (1966): Mechanisms of chemical carcinogenesis: Nature of proximate carcinogens and interactions with macromole-cules. Pharmacol Rev 18: 805–838.
- Mirsalis JC, Monforte JA, Winegar RA (1994): Transgenic animal models for measuring mutations in vivo. Crit Rev Toxicol (in press).
- Mullis K, Faloona F, et al. (1992): Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. 1986 {classical article. Biotechnology 24: 17–27.
- Nathans D, Smith HO (1975): Restriction endonucleases in the analysis and restructuring of DNA molecules. Annu Rev Biochem 44: 273–293.
- Robbins WA, Segraves R, Pinkel D, Wyrobek AJ (1993): Detection of aneuploid sperm by fluorescence in situ hybridization: evidence for a donor difference in frequency of sperm disomic for chromosomes I and Y. Am J Hum Genet 52: 799–807.
- Sanger F (1981): Determination of nucleotide sequences in DNA. Biosci Rep 1: 3–18.
- Sanger F, Air GM, Barrell BG, Brown ML, Coulson AR, Fiddes JC, Hutchison CA III, Slocombe PM, Smith M (1977a): Nucleotide sequence of ΦX-174 DNA. Nature 265: 687–695.
- Sanger F, Nicklen S, Coulson AR (1977b): DNA sequencing with chainterminating inhibitors. Proc Natl Acad Sci USA 74: 5463–5467.
- Sarasin A (1985): SOS response in mammalian cells. Cancer Invest 3: 163–174.
- Singh NP, McCoy MT, Tice RR, Schneider EL (1988): A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175: 184–191.
- Speyer JF, Lengyel P, Basilio C, Wahba AH, Gardner RS, Ochoa S (1963): Synthetic polynucleotides and the amino acid code. Cold Spring Harbor Symp Quant Biol 28: 559–568.
- Tice RR, Andrews PW, Hirai O, Singh NP (1991): The single cell gell (SCG) assay: An electrophoretic technique for detection of DNA damage in individual cells. Adv Exp Med Biol 283: 157–164.
- Tucker J, Ramsey MJ, Lee DA, Minkler JL (1993): Validation of chromosome painting as a biodosimeter in human peripheral blood lymphocytes following acute exposure to ionizing radiation in vitro. Int J Radiat Biol 64: 27–37.
- VanBogelen R, Kelley PM, Neidhardt FC (1987): Differential induction of heat shock, SOS and oxidation stress regulons and accumulation of nucleotides in Escherichia coli. J Bacteriol 169: 26–32.
- Varmus HE (1984): The molecular genetics of cellular oncogenes. Annu Rev Genet 18: 553–612.
-
Varmus HE
(1985):
Viruses, genes, and cancer. 1. The discovery of cellular oncogenes and their role in neoplasia.
Cancer
55: 2324–2328.
10.1002/1097-0142(19850515)55:10<2324::AID-CNCR2820551004>3.0.CO;2-A CAS PubMed Web of Science® Google Scholar
-
Walker GC
(1984):
Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli.
Microbiol Rev
48: 60–93.
10.1016/j.dnarep.2007.07.015 Google Scholar
- Wassom JS (1989): Origins of genetic toxicology and the Environmental Mutagen Society. Environ Mol Mutagen 14(Suppl. 16); 1–6.
- Watson JD, Crick FHC (1953): Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid. Nature 171: 737–738.
- Welch WJ, Mizzen LA, Arrigo AP (1989): Structure and function of mammalian stress proteins. In ML Pardue, JR Fermisco, S Lindquist (eds): “ Proteins.” New York: Alan R. Liss, p 187.
- Witkowski JA (1988): The discovery of ‘split’ genes: a scientific revolution. Trends Biochem Sci 13: 110–113.