Future of germ cell cytogenetics

Corresponding Author

R. Julian Preston

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina

Chemical Industry Institute of Toxicology. 6 Davis Drive, P.O. Box 12137. Research Triangle Park. NC 27709Search for more papers by this author

R. Julian Preston,

Corresponding Author

R. Julian Preston

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina

Chemical Industry Institute of Toxicology. 6 Davis Drive, P.O. Box 12137. Research Triangle Park. NC 27709Search for more papers by this author

First published: 1994

https://doi.org/10.1002/em.2850230613

Citations: 6

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Abstract

The celebration of the 25th Anniversary of the Environmental Mutagen Society provides an excellent opportunity to assess the status of research in a broad range of areas, with an emphasis on the directions in which they are going. This chapter concentrates on the analysis of chromosomal alterations in mammalian germ cells.

The future developments in germ cell cytogenetics research will build heavily upon techniques developed over the past 25 years. With these it is possible to assess numerical and structural alterations in the male in differentiating spermatogonia, spermatocytes, and post-mei-otic cells (at the first cleavage division) and for the female in oocytes and the zygote. The most predictable advances will be in the identification of specific alterations through FISH of interphase spermatozoa in humans and further improvements with the human sperm/hamster egg in vitro fertilization technique. Of particular importance is the fact that this will allow for the study of effects in human germ cells. From a more speculative viewpoint it might be possible to assess the role of particular genomic organization on genetic outcomes by direct observation; these might include genomic imprinting and the visual separation of male and female genomes. The overall aim of germ cell cytogenetic studies will remain as improving our ability to identify and estimate the true genetic risk in humans. © 1994 Wiley-Liss, Inc.

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Volume23, IssueS2

Supplement: Special Issue. In Commemoration of the 25th Anniversary of the Environmental Mutagen Society

1994

Pages 54-58

Future of germ cell cytogenetics

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