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Functional interleukin 2 receptors on B cells lacking Tac antigens
Abstract
Human B lymphoblastoid line, SKW 6-4, cells were induced to IgM-secreting cells by high concentrations of interleukin 2 (IL2). These cells were found to be unreactive with anti-Tac antibody and did not express mRNA detectable for Tac antigen. In Scatchard plot analysis, low-affinity IL 2-binding sites were found on SKW 6-4 cells. Moreover, analysis of the IL2-binding molecules revealed ones (molecular weight 70000 and 75000) distinct from Tac antigen. It is conceivable that IL2 exerts its effect through its interaction with these novel IL2-binding molecules in SKW 6-4 cells.
