Clinical backgrounds and outcomes of patients with Barrett's esophageal adenocarcinoma treated via endoscopic submucosal dissection in Kyushu, Japan: A retrospective multicenter cohort study
Corresponding Author
Fumisato Sasaki
Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Correspondence
Fumisato Sasaki, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Email: [email protected]
Search for more papers by this authorKazuhiro Mizukami
Department of Gastroenterology, Oita University, Oita, Japan
Search for more papers by this authorTaro Akashi
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Search for more papers by this authorNaoyuki Yamaguchi
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Search for more papers by this authorRyosuke Gushima
Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Search for more papers by this authorHideaki Miyamoto
Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Search for more papers by this authorShohei Uehara
Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Search for more papers by this authorYoichiro Ono
Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
Search for more papers by this authorTakashi Hisabe
Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
Search for more papers by this authorYuzuru Kinjo
Department of Gastroenterology, Naha City Hospital, Okinawa, Japan
Search for more papers by this authorYuichiro Nasu
Division of Gastroenterology, Kagoshima City Hospital, Kagoshima, Japan
Search for more papers by this authorKensuke Fukuda
Department of Gastroenterology, Oita University, Oita, Japan
Search for more papers by this authorTaisuke Inada
Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka, Japan
Search for more papers by this authorYorinobu Sumida
Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka, Japan
Search for more papers by this authorTakashi Akutagawa
Department of Endoscopic Diagnostics and Therapeutics Saga University Hospital, Saga, Japan
Search for more papers by this authorTadashi Miike
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Search for more papers by this authorSho Suzuki
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Search for more papers by this authorHiroki Fukuya
Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
Search for more papers by this authorMichita Mukasa
Department of Medicine, Division of Gastroenterology, Kurume University School of Medicine, Fukuoka, Japan
Search for more papers by this authorMitsuru Esaki
Department of Gastroenterology, Harasanshin Hospital, Fukuoka, Japan
Search for more papers by this authorShinsuke Kumei
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
Search for more papers by this authorYosuke Minoda
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Search for more papers by this authorTetsu Kinjo
Department of Endoscopy, University of the Ryukyus Hospital, Okinawa, Japan
Search for more papers by this authorDaisuke Yamaguchi
Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Saga, Japan
Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, Saga University, Saga, Japan
Search for more papers by this authorYoshio Fukuda
Division of Gastroenterology, Kagoshima Kouseiren Hospital, Kagoshima, Japan
Search for more papers by this authorKazutoshi Hashiguchi
Department of Gastroenterology, Imamura Hospital, Saga, Japan
Search for more papers by this authorHiroki Yano
Division of Gastroenterology, Oshima Prefectural Hospital, Kagoshima, Japan
Search for more papers by this authorHiroshi Fujita
Division of Gastroenterology, Izumi General Medical Center, Kagoshima, Japan
Search for more papers by this authorRyo Shimoda
Department of Endoscopic Diagnostics and Therapeutics Saga University Hospital, Saga, Japan
Search for more papers by this authorGI-Kysuhu study group
Search for more papers by this authorCorresponding Author
Fumisato Sasaki
Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Correspondence
Fumisato Sasaki, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Email: [email protected]
Search for more papers by this authorKazuhiro Mizukami
Department of Gastroenterology, Oita University, Oita, Japan
Search for more papers by this authorTaro Akashi
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Search for more papers by this authorNaoyuki Yamaguchi
Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Search for more papers by this authorRyosuke Gushima
Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Search for more papers by this authorHideaki Miyamoto
Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Search for more papers by this authorShohei Uehara
Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Search for more papers by this authorYoichiro Ono
Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
Search for more papers by this authorTakashi Hisabe
Department of Gastroenterology, Fukuoka University Chikushi Hospital, Fukuoka, Japan
Search for more papers by this authorYuzuru Kinjo
Department of Gastroenterology, Naha City Hospital, Okinawa, Japan
Search for more papers by this authorYuichiro Nasu
Division of Gastroenterology, Kagoshima City Hospital, Kagoshima, Japan
Search for more papers by this authorKensuke Fukuda
Department of Gastroenterology, Oita University, Oita, Japan
Search for more papers by this authorTaisuke Inada
Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka, Japan
Search for more papers by this authorYorinobu Sumida
Department of Gastroenterology, Kitakyushu Municipal Medical Center, Fukuoka, Japan
Search for more papers by this authorTakashi Akutagawa
Department of Endoscopic Diagnostics and Therapeutics Saga University Hospital, Saga, Japan
Search for more papers by this authorTadashi Miike
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Search for more papers by this authorSho Suzuki
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
Search for more papers by this authorHiroki Fukuya
Department of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan
Search for more papers by this authorMichita Mukasa
Department of Medicine, Division of Gastroenterology, Kurume University School of Medicine, Fukuoka, Japan
Search for more papers by this authorMitsuru Esaki
Department of Gastroenterology, Harasanshin Hospital, Fukuoka, Japan
Search for more papers by this authorShinsuke Kumei
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan
Search for more papers by this authorYosuke Minoda
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Search for more papers by this authorTetsu Kinjo
Department of Endoscopy, University of the Ryukyus Hospital, Okinawa, Japan
Search for more papers by this authorDaisuke Yamaguchi
Department of Gastroenterology, National Hospital Organization Ureshino Medical Center, Saga, Japan
Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, Saga University, Saga, Japan
Search for more papers by this authorYoshio Fukuda
Division of Gastroenterology, Kagoshima Kouseiren Hospital, Kagoshima, Japan
Search for more papers by this authorKazutoshi Hashiguchi
Department of Gastroenterology, Imamura Hospital, Saga, Japan
Search for more papers by this authorHiroki Yano
Division of Gastroenterology, Oshima Prefectural Hospital, Kagoshima, Japan
Search for more papers by this authorHiroshi Fujita
Division of Gastroenterology, Izumi General Medical Center, Kagoshima, Japan
Search for more papers by this authorRyo Shimoda
Department of Endoscopic Diagnostics and Therapeutics Saga University Hospital, Saga, Japan
Search for more papers by this authorGI-Kysuhu study group
Search for more papers by this authorAbstract
Objectives
Most esophageal cancers in Japan are squamous cell carcinomas; however, there has been some concern regarding a recent increase in Barrett's esophageal adenocarcinoma (BEA). This study aimed to clarify the clinical characteristics and outcomes of patients treated via endoscopic submucosal dissection (ESD) in Kyushu, including changes over time.
Methods
This multicenter, retrospective, observational study was conducted among 21 institutes situated in Kyushu. Data from patients who underwent ESD for BEA or esophageal squamous cell carcinoma between January 2010 and December 2023 were extracted from the pathology database and reviewed.
Results
The total number of esophageal ESD cases increased from 2299 over the first 7 years to 4009 over the second seven. The incidence of BEA increased from 3.6% (86/2299) over the earlier period to 4.7% (197/4009; p = 0.034) over the latter. We analyzed data from 283 patients (287 lesions). Smaller tumor-sized lesions were detected over the latter period (14.2 ± 11.6 vs. 11.2 ± 9.5 cm2, p = 0.022), significantly reducing treatment times (122.1 ± 81.2 vs. 93.2 ± 53.3 min p < 0.001). The procedure was safe, with low incidence rates, over both the earlier and later periods (respectively), of perforation (0% vs. 1.0%), delayed bleeding (1.2% vs. 2.0%), and pneumonia (4.7% vs. 4.6%).
Conclusion
The proportion of esophageal ESD procedures to treat BEA has increased in Japan's Kyushu region. This procedure has a comparable safety profile to similar ESD procedures used to treat other conditions.
CONFLICT OF INTEREST STATEMENT
None.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
| Filename | Description |
|---|---|
| deo270102-sup-0001-SuppMat.docx18.2 KB | DATA S1 Clinical and pathological characteristics of patients with recurrence. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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