Volume 15, Issue 7 e70360
LETTER TO THE JOURNAL
Open Access

Early molecular changes predict cancer cachexia in LKB1-deleted mouse models of NSCLC

Gloriana Ndembe

Gloriana Ndembe

Laboratory of Molecular Pharmacology, Experimental Oncology Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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Andrea David Re Cecconi

Andrea David Re Cecconi

Laboratory of Muscle Pathophysiology, Neuroscience Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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Federica Palo

Federica Palo

Laboratory of Muscle Pathophysiology, Neuroscience Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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Dorina Belotti

Dorina Belotti

Laboratory of Tumor Microenvironment, Experimental Oncology Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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Laura Sala

Laura Sala

Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy

Mouse & Animal Pathology Lab, Fondazione UniMi, Milan, Italy

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Selena Foroni

Selena Foroni

Laboratory of Molecular Pharmacology, Experimental Oncology Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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Eugenio Scanziani

Eugenio Scanziani

Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy

Mouse & Animal Pathology Lab, Fondazione UniMi, Milan, Italy

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Rosanna Piccirillo

Rosanna Piccirillo

Laboratory of Muscle Pathophysiology, Neuroscience Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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Massimo Broggini

Corresponding Author

Massimo Broggini

Laboratory of Molecular Pharmacology, Experimental Oncology Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

Correspondence

Massimo Broggini, Laboratory of Molecular Pharmacology, Experimental Oncology Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milan, Italy.

Email: [email protected]

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Mirko Marabese

Mirko Marabese

Laboratory of Molecular Pharmacology, Experimental Oncology Department, Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy

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First published: 23 July 2025

Gloriana Ndembe and Andrea David Re Cecconi are co-first authors.

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DATA AVAILABILITY STATEMENT

Data generated or analysed during this study are included in this published article and its supporting information files. All the raw data are available upon request from the corresponding author.

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