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Differential complementary localization of metabolic enzymes for quinolinic acid in olfactory bulb astrocytes
Michael R. Poston,
Mary S. Bailey,
Robert Schwarcz,
Michael T. Shipley,
Michael R. Poston
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Search for more papers by this authorMary S. Bailey
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Search for more papers by this authorRobert Schwarcz
Maryland Psychiatric Research Center, Baltimore, Maryland 21228
Search for more papers by this authorMichael T. Shipley
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Search for more papers by this authorMichael R. Poston,
Mary S. Bailey,
Robert Schwarcz,
Michael T. Shipley,
Michael R. Poston
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Search for more papers by this authorMary S. Bailey
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Search for more papers by this authorRobert Schwarcz
Maryland Psychiatric Research Center, Baltimore, Maryland 21228
Search for more papers by this authorMichael T. Shipley
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267
Search for more papers by this authorAbstract
The cellular localizations of the synthetic [3-hydroxyanthranilic acid oxygenase (3HAO)] and degradative [quinolinic acid phosphoribosyltransferase (QPRT)] enzymes of the endogenous excitotoxin quinolinic acid were studied in the adult rat main olfactory bulb by immunohistochemical techniques. 3HAO and QPRT were expressed only in astrocytes. The two enzymes were differentially expressed by astrocytes in a complementary pattern: 3HAO staining was strongest at the glomerular–external plexiform layer junction; QPRT staining was strongest at the glomerular–olfactory nerve layer junction. The complementary distributions of these metabolic enzymes suggests that there could be a gradient of quinolinic acid across the glomerular layer of the main olfactory bulb. Such a gradient could function to restrict the ingrowth of new olfactory axons to the glomeruli and/or to stabilize the formation of new synapses.
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