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The glycoconjugate of Helicobacter pylori serotype O2 O-antigen fragment HPO2G-3a-CRM197 can elicit a robust IgG immune response in rabbits, which possesses a strong binding affinity with LPS and bacteria of H. pylori O2. The trisaccharide HPO2G-3a is a promising candidate for H. pylori vaccine development. More details are discussed in the article by Yin et al. on page 243—251.