Concise Report
Palladium-Catalyzed Carbonylation of ortho-Alkenyl Iodobenzenes for the Construction of 3-Arylindenones
Minxiu Qian,
Lingyun Yao,
Zhi Li,
Xusheng Shao,
Quannan Wang,
Wei-Ping Deng,
Minxiu Qian
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
Search for more papers by this authorLingyun Yao
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
Search for more papers by this authorZhi Li
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
Search for more papers by this authorXusheng Shao
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
Search for more papers by this authorCorresponding Author
Quannan Wang
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Wei-Ping Deng
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
E-mail: [email protected]; [email protected]Search for more papers by this authorMinxiu Qian,
Lingyun Yao,
Zhi Li,
Xusheng Shao,
Quannan Wang,
Wei-Ping Deng,
Minxiu Qian
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
Search for more papers by this authorLingyun Yao
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
Search for more papers by this authorZhi Li
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
Search for more papers by this authorXusheng Shao
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237 China
Search for more papers by this authorCorresponding Author
Quannan Wang
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Wei-Ping Deng
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua, Zhejiang, 321004 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
We developed a novel Pd-catalyzed carbonylation of ortho-alkenyl iodobenzenes with CO, affording a diverse array of 3-arylindenones in good to excellent yields (up to 94% yield). This methodology exhibits broad substrate scope and good functional group compatibility. The synthetic utility was demonstrated by a gram-scale reaction, diverse product derivatizations, and the preparation of an intermediate for a PPARγ agonist.
Supporting Information
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Appendix S1: Supporting Information |
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