Catalytic Difunctionalization of Alkenes under Visible Light Irradiation: Synthesis of Iminofuranones
Boyu Liu
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorGuangxian Chen
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorLele Zhang
Key Laboratory of Chemical Genomics of Guangdong Province, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, 518055 China
Search for more papers by this authorFeiwei Yan
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorFeiming Li
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorZhixiong Cai
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorMingqiang Huang
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorLina Cai
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorCorresponding Author
Shunyou Cai
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Key Laboratory of Chemical Genomics of Guangdong Province, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, 518055 China
E-mail: [email protected]Search for more papers by this authorBoyu Liu
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorGuangxian Chen
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorLele Zhang
Key Laboratory of Chemical Genomics of Guangdong Province, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, 518055 China
Search for more papers by this authorFeiwei Yan
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorFeiming Li
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorZhixiong Cai
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorMingqiang Huang
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorLina Cai
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Search for more papers by this authorCorresponding Author
Shunyou Cai
Key Laboratory of Modern Analytical Science and Separation Technology of Fujian Province, School of Chemistry Chemical Engineering, and Environment, Minnan Normal University, Zhangzhou, Fujian, 363000 China
Key Laboratory of Chemical Genomics of Guangdong Province, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, Guangdong, 518055 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
Here, we show a cost-effective and environmentally friendly method for synthesizing iminofuranones using visible light and the photocatalyst 2-bromoanthraquinone. Our approach uses only oxygen as the oxidant, avoiding the need for additional transition metals and strong oxidizing agents. By employing a mixed solvent system of DMF and CHCl3 under ambient conditions, we have achieved highly diastereoselective conversions of various 2-vinyl benzamides and alkenyl amides into functionalized iminoisobenzofuranones and iminofuranones. This versatile process is broadly applicable and enables late-stage structural modifications of complex substrates with bioactive moieties.
Supporting Information
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| cjoc202401116-sup-0001-supinfo.pdfPDF document, 19.4 MB |
Appendix S1: Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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