Bioinspired Coordination for Fabricating Self-healing and Injectable Hydrogels with Antibacterial and Immunoregulatory Activities†
Youlu Diao
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
The authors contributed equally to this work.
Search for more papers by this authorJia Gao
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
The authors contributed equally to this work.
Search for more papers by this authorXinrui Li
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
† Dedicated to the Special Issue of Biomimetic Materials.
Search for more papers by this authorCorresponding Author
Miao Wang
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Guoqing Pan
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
E-mail: [email protected]; [email protected]Search for more papers by this authorYoulu Diao
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
The authors contributed equally to this work.
Search for more papers by this authorJia Gao
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
The authors contributed equally to this work.
Search for more papers by this authorXinrui Li
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
† Dedicated to the Special Issue of Biomimetic Materials.
Search for more papers by this authorCorresponding Author
Miao Wang
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Guoqing Pan
Institute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, 301 Xuefu Rd, Zhenjiang, Jiangsu, 212013 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Inspired by the molecular mechanism of mussel adhesion, here, we developed a class of injectable and self-healing hydrogels based on natural polysaccharide hyaluronic acid (HA). The dynamic property of hydrogels is derived from histidine-metal coordination, which widely exists in the mussel adhesive plaque. To mimic components of mussel byssal threads, we first grafted histidine-containing peptides onto the HA chains. Followed by the addition of Zn2+ ions, the modified HA could then transform into a pH-sensitive hydrogel network (HA-His-Zn) with tunable sol-gel transitions. The dynamic metal-ligand coordination could significantly enhance the mechanical properties of HA hydrogels and also endow them with self-healing and injectable abilities. In addition, the HA-His-Zn hydrogels could also exhibit antibacterial and immunoregulatory activities due to the bioactive Zn2+ ions. These results, together with the dynamic properties and good biocompatibility, indicated that the HA-His-Zn hydrogels could be applied as a class of easy-to-handle scaffold materials for regeneration medicine, particularly for tissue traumas with chronic inflammations and infections.
Supporting Information
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