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Proteus mirabilis and Proteus vulgaris are zoonotic pathogens which can cause public health disease. Owing to their antibiotic-resistance, developing vaccines against these pathogens is urgently required. Herein, we describe the first synthesis of the common O-antigen (trisaccharide to nonasaccharide) of Proteus mirabilis OE and Proteus vulgaris TG 103. Two challenging 1,2-cis-glycosidic bonds were successfully constructed by use of conformation-restrained donors under bifunctional organothiourea catalysis or gold(I) catalysis. A primary immunological evaluation was carried out and the results revealed that the synthetic common O-antigens both hexasaccharide and nonasaccharide can strongly bind with the IgG antibodies in the sera. More details are discussed in the article by Zhang et al. on page 535—543.