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A hollow polydopamine/Zn (HPDA/Zn) ultrasound contrast agent is exploited. In addition to having a good contrast-enhancement capability in ultrasound imaging, HPDA/Zn can also stabilize plaque by inhibiting CREB and reducing plaque-vulnerable markers and inflammatory factors, achieving the treatment of atherosclerosis. More details are discussed in the article by Wu et al. on page 199—206.