Concise Report
Nickel-Catalyzed Stereoselective Migratory Carboboration of 1,4-Cyclohexadiene†
Yaoyu Ren,
Lujin Wang,
Chao Ding,
Yangyang Li,
Guoyin Yin,
Yaoyu Ren
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorLujin Wang
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorChao Ding
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorCorresponding Author
Yangyang Li
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Guoyin Yin
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
E-mail: [email protected]; [email protected]Search for more papers by this authorYaoyu Ren,
Lujin Wang,
Chao Ding,
Yangyang Li,
Guoyin Yin,
Yaoyu Ren
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorLujin Wang
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorChao Ding
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorCorresponding Author
Yangyang Li
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Guoyin Yin
The Institute for Advanced Studies, Wuhan University, Wuhan, Hubei, 430072 China
E-mail: [email protected]; [email protected]Search for more papers by this author†Dedicated to the Memory of Professor Xiyan Lu.
Comprehensive Summary
Multi-substituted cyclohexanes play a crucial role as scaffolds in bioactive compounds. While significant progress has been made in synthesizing substituted cyclohexanes, methods for the stereoselective assembly of 1,3-disubstituted cyclohexanes remain scarce. This study presents a novel approach involving nickel catalysis to achieve stereoselective carboboration of 1,4-cyclohexadiene. This innovative process allows for the simultaneous introduction of a boron group and an aryl or an alkyl fragment into the 1,4-cyclohexadiene framework under mild conditions, with exclusive regioselectivity and excellent cis configuration. The resulting products feature a double carbon bond and the incorporation of the boron group, offering significant potential for subsequent transformations and downstream applications.
Supporting Information
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Appendix S1: Supporting Information |
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