Decarboxylative Amination with Nitroarenes via Synergistic Catalysis†
Meiling Ding
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorSitian Zhou
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorShunruo Yao
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorChengjian Zhu
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001 China
Search for more papers by this authorCorresponding Author
Weipeng Li
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jin Xie
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]Search for more papers by this authorMeiling Ding
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorSitian Zhou
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorShunruo Yao
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorChengjian Zhu
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001 China
Search for more papers by this authorCorresponding Author
Weipeng Li
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jin Xie
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu, 210023 China
E-mail: [email protected]; [email protected]Search for more papers by this author†Dedicated to the Memory of Professor Xiyan Lu.
Comprehensive Summary
In this paper, we have developed a decarboxylative amination of carboxylic acids with nitroarenes for the synthesis of secondary amines. The protocol is performed at mild conditions without the use of noble metals as catalysts. A wide range of structurally diverse secondary amines could be obtained in good yields (up to 94%) with good functional group tolerance. This transformation shows good to excellent selectivity, avoiding the generation of over alkylated byproducts.
Supporting Information
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Appendix S1: Supporting Information |
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