Concise Report
Cobalt-Catalyzed Difunctionalization of Styrenes via Ligand Relay Catalysis†
Bingcheng Wang,
Yufeng Sun,
Zhan Lu,
Bingcheng Wang
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorYufeng Sun
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorCorresponding Author
Zhan Lu
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310058 China
College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001 China
E-mail: [email protected]Search for more papers by this authorBingcheng Wang,
Yufeng Sun,
Zhan Lu,
Bingcheng Wang
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorYufeng Sun
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorCorresponding Author
Zhan Lu
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310058 China
College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001 China
E-mail: [email protected]Search for more papers by this author†
Dedicated to the Memory of Professor Xiyan Lu.
Comprehensive Summary
Here, we report a cobalt-catalyzed sequential dehydrogenative Heck silylation/hydroamination of styrenes with hydrosilane and diazo compound to access 1-amino-2-silyl compounds with excellent regioselectivity. This difunctionalization reaction could undergo smoothly using 1 mol% catalyst loading with good functional group tolerance. Not only di- and tri-substituted hydrosilanes, but also alkoxysilane is suitable, which does explore the scope of the family of 1-amino-2-silyl compounds. The ligand relay phenomenon between neutral tridentate NNN ligand and anionic NNN ligand is observed for the first time via absorption spectral analysis in this one-pot, two-step transformations. The primary mechanism has been proposed based on the control experiments.
Supporting Information
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Appendix S1: Supporting Information |
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