Photo-triggered Intramolecular Radical Tandem Regioselective Alkylation/Cyclization of 1,6-Dienes with Redox-Active Esters Enabled by an EDA Complex
Bin Sun
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorLan Ling
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorXiaohui Zhuang
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorLulu Yang
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorJieli Yin
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorCorresponding Author
Can Jin
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
E-mail: [email protected]Search for more papers by this authorBin Sun
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorLan Ling
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorXiaohui Zhuang
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorLulu Yang
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorJieli Yin
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
Search for more papers by this authorCorresponding Author
Can Jin
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014 China
E-mail: [email protected]Search for more papers by this authorComprehensive Summary
A photocatalyst- and metal-free radical tandem alkylation/cyclization between 1,6-dienes and redox-active esters has been developed, affording a series of N-aryl pyrrolidine-2-ones in moderate to good yields. The transformation is driven by the formation of an electron-donor-acceptor (EDA) complex and a subsequent single electron transfer (SET) process. This photocatalyst-free protocol features excellent regioselectivity, mild conditions and broad substrate scope, providing a facile access to 3-alkyl-3,4-dimethyl-1-phenylpyrrolidin-2-one.
Supporting Information
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