Clerodenoids A—F: C-ring Aromatized and/or Rearranged Abietane Diterpenoids from Clerodendrum chinense var. simplex
Jingjing Qi
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorYan Zhang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
Search for more papers by this authorQunfang Liu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
Search for more papers by this authorCorresponding Author
Hongchun Liu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yaoyue Fan
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jianmin Yue
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorJingjing Qi
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023 China
Search for more papers by this authorYan Zhang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
Search for more papers by this authorQunfang Liu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
Search for more papers by this authorCorresponding Author
Hongchun Liu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Yaoyue Fan
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Jianmin Yue
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu, 210023 China
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203 China
E-mail: [email protected]; [email protected]; [email protected]Search for more papers by this authorMain observation and conclusion
As part of our continuing efforts toward the discovery of the biologically active diterpenoids from medicinal plants, six new C-ring aromatized abietane diterpenoids, clerodenoids A—F (1—6), were isolated from Clerodendrum chinense. These C-ring aromatized compounds mainly belonged to the rearranged abietane skeletons of 17(15→16)-abeo-abietane (2—4) and 17(15→16), 18(4→3)-diabeo-abietane (5 and 6). Their structures were elucidated by extensive spectroscopic data, X-ray crystallography, and ECD calculation. Compounds 5 and 6 displayed strong antiproliferative activities against A549 and HL-60 cell lines.
Supporting Information
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