Cornerstones in Chemistry
Phosphorus Ligands from the Zhang Lab: Design, Asymmetric Hydrogenation, and Industrial Applications
Feng Wan,
Wenjun Tang,
Feng Wan
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 China
Search for more papers by this authorCorresponding Author
Wenjun Tang
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 China
School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou, Zhejiang, 310024 China
E-mail: [email protected]Search for more papers by this authorFeng Wan,
Wenjun Tang,
Feng Wan
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 China
Search for more papers by this authorCorresponding Author
Wenjun Tang
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032 China
School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou, Zhejiang, 310024 China
E-mail: [email protected]Search for more papers by this authorAbstract
Chiral phosphorus ligands have played a crucial role for the recent advances in asymmetric catalysis. This review summarizes chiral phosphorus ligands developed from the Laboratory of Professor Xumu Zhang in the latest 25 years. A number of iconic phosphorus ligands including bisphosphorus ligands with rigid chiral backbone such as BICP, PennPhos, TunePhos, and f-Binaphane, P-chiral bisphosphorus ligands TangPhos, Binapine, and DuanPhos, phosphine-phosphoramidte ligand YanPhos, noncovalent interaction-assisted ferrocenyl phosphorus ligand ZhaoPhos and WudaPhos, and tridentate ferrocenyl phosphorus ligands f-amphox are introduced, and their applications in asymmetric hydrogenation are emphasized.
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