Iron-Catalyzed Aminomethyloxygenative Cyclization of Hydroxy-α-diazoesters with N,O-Aminals
Suchen Zou
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
Search for more papers by this authorTianze Zhang
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
Search for more papers by this authorSiyuan Wang
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
Search for more papers by this authorCorresponding Author
Hanmin Huang
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, 730000 China
E-mail: [email protected]Search for more papers by this authorSuchen Zou
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
Search for more papers by this authorTianze Zhang
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
Search for more papers by this authorSiyuan Wang
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
Search for more papers by this authorCorresponding Author
Hanmin Huang
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, Chinese Academy of Sciences, Hefei, Anhui, 230026 China
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, 730000 China
E-mail: [email protected]Search for more papers by this authorSummary of main observation and conclusion
A new and efficient cyclization reaction has been developed to synthesize cyclic α,α-disubstituted β-amino esters via iron-catalyzed intramolecular aminomethyloxygenative cyclization of diazo compounds with N,O-aminal under mild reaction conditions. A broad range of hydroxy-α-diazoesters with different substituents and various N,O-aminals were compatible with this protocol, affording the corresponding α,α-disubstituted β-amino esters bearing a five- to eight-membered oxacycle in good yields.
Supporting Information
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