Cornerstones in Chemistry
Click Chemistry: Evolving on the Fringe
Long Xu,
Jiajia Dong,
Long Xu
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 China
Search for more papers by this authorCorresponding Author
Jiajia Dong
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 China
E-mail: [email protected]Search for more papers by this authorLong Xu,
Jiajia Dong,
Long Xu
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 China
Search for more papers by this authorCorresponding Author
Jiajia Dong
Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai, 200032 China
E-mail: [email protected]Search for more papers by this authorSummary
The article herein briefly introduces the story of the birth of click chemistry and its evolution after that. A new angle to interpret click reactions was proposed using the “reactivity-availability-functionality” trilogy. CuAAC (Copper-catalyzed azide-alkyne cycloaddition), the most popular click reaction by far, was revisited along with the thiol-ene, metal-free AAC, SuFEx (Sulfur(VI) fluoride exchange) and the lately discovered diazotransfer process. By encountering more and more near-perfect reactions, click chemistry is evolving and expanding on the fringe of the chemistry and different scientific disciplines, destination unknown.
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