Fluorescence Responses of the Protonation and Deprotonation Processes between Phenolate and Phenol within Rosamine
Ling Yang
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
These authors contributed equally.Search for more papers by this authorJinyun Niu
School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, China
These authors contributed equally.Search for more papers by this authorYanhua Zhan
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
Search for more papers by this authorCorresponding Author
Yujie Xu
School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, China
E-mail: [email protected], [email protected]; Tel. & Fax: 0086- 0512-65884717Search for more papers by this authorRu Sun
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
Search for more papers by this authorCorresponding Author
Jianfeng Ge
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical, Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China
E-mail: [email protected], [email protected]; Tel. & Fax: 0086- 0512-65884717Search for more papers by this authorLing Yang
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
These authors contributed equally.Search for more papers by this authorJinyun Niu
School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, China
These authors contributed equally.Search for more papers by this authorYanhua Zhan
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
Search for more papers by this authorCorresponding Author
Yujie Xu
School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, China
E-mail: [email protected], [email protected]; Tel. & Fax: 0086- 0512-65884717Search for more papers by this authorRu Sun
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
Search for more papers by this authorCorresponding Author
Jianfeng Ge
College of Chemistry, Chemical Engineering and Material Science, Soochow University, 199 Ren'Ai Road, Suzhou, Jiangsu 215123, China
Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical, Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China
E-mail: [email protected], [email protected]; Tel. & Fax: 0086- 0512-65884717Search for more papers by this authorAbstract
Two rosamine-based pH probes 1a and 1b with pyronine-phenol skeleton were designed and synthesized by a simple one-step reaction. pH titration experiments showed that probes 1a and 1b exhibit near OFF–ON fluorescence responses around 550–750 nm towards the hydrogen ions. The pKa of the probe 1a is 8.29, while that of the probe 1b increases to 12.1 because of the hydrogen bond inside it. Selective and competitive experiments indicated that both common ions and amino acids did not interfere their emission with hydrogen ions. Moreover, confocal fluorescent imaging showed that the probe 1a could be served as mitochondria biomarker in HeLa and Ges-1 cells.
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