Hyaluronic Acid-Gadolinium Complex Nanospheres as Lymphatic System-Specific Contrast Agent for Magnetic Resonance Imaging
Guangyu Wu
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Search for more papers by this authorHuajuan Zhang
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Search for more papers by this authorZufeng Zhan
Orthopedic Surgery, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, China
Search for more papers by this authorQing Lu
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Search for more papers by this authorJiejun Cheng
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Search for more papers by this authorCorresponding Author
Jianrong Xu
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Jianrong Xu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China, Tel.: 0086-021-68383258; Fax: 0086-021-563736075
Jun Zhu, National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Search for more papers by this authorCorresponding Author
Jun Zhu
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Jianrong Xu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China, Tel.: 0086-021-68383258; Fax: 0086-021-563736075
Jun Zhu, National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Search for more papers by this authorGuangyu Wu
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Search for more papers by this authorHuajuan Zhang
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Search for more papers by this authorZufeng Zhan
Orthopedic Surgery, Taihe Hospital, Affiliated Hospital of Hubei University of Medicine, Shiyan, Hubei 442000, China
Search for more papers by this authorQing Lu
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Search for more papers by this authorJiejun Cheng
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Search for more papers by this authorCorresponding Author
Jianrong Xu
Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Jianrong Xu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China, Tel.: 0086-021-68383258; Fax: 0086-021-563736075
Jun Zhu, National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Search for more papers by this authorCorresponding Author
Jun Zhu
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Jianrong Xu, Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China, Tel.: 0086-021-68383258; Fax: 0086-021-563736075
Jun Zhu, National Engineering Research Center for Nanotechnology, Shanghai 200241, China
Search for more papers by this authorAbstract
A novel MRI contrast agent, hyaluronic acid gadolinium complex (HA-Gd-DTPA) nanospheres, is prepared by the synthesis of hyaluronic acid gadolinium complexes and their assembly. The physicochemical properties are characterized, and the lymphatic targeting in vitro and in vivo are also evaluated. The results show that the HA-Gd-DTPA nanospheres with suitable and stable physicochemical properties could be used for in vivo lymphatic targeting studies. Furthermore, the HA-Gd-DTPA nanospheres have obviously higher relaxation efficiency and MRI contrast between blood vessel and lymph vessel in rabbit than that of Magnevist. Thus, the novel MRI contrast agent can be taken up selectively by lymphatic system and used as a potential MRI contrast agents in lymphatic system.
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