Directly Regioselective Protection of Secondary Hydroxyl Group on Ribosides in Aqueous Solution
Ruigang Xu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorFei Liu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorYingju Liu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorBeiqing Chen
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorCorresponding Author
Feng-Wu Liu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, ChinaSearch for more papers by this authorRuigang Xu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorFei Liu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorYingju Liu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorBeiqing Chen
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
Search for more papers by this authorCorresponding Author
Feng-Wu Liu
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, ChinaSearch for more papers by this authorAbstract
Selective benzoylation of secondary hydroxyl on sugar moiety of various ribosides including N-ribosides, O-ribosides and 2′-deoxy-N-riboside was investigated by using benzoyl chloride and Na2CO3 in aqueous CH3CN. The influence of the aglycone and sugar moiety on the selectivity of benzoylation was discussed as well. A most efficient method for preparation of 2′,3′-O-dibenzoylnucleosides was developed.
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