Volume 30, Issue 10 pp. 2292-2296
Full Paper

Sugar-fiber Imprinting to Generate Microgrooves on Polymeric Film Surfaces for Contact Guidance of Cells

Zehua Qu

Zehua Qu

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Advanced Materials Laboratory, Fudan University, Shanghai 200433, China

Search for more papers by this author
Jiandong Ding

Corresponding Author

Jiandong Ding

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Advanced Materials Laboratory, Fudan University, Shanghai 200433, China

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Advanced Materials Laboratory, Fudan University, Shanghai 200433, China, Tel.: 0086-21-65643506; Fax: 0086-21-65640293Search for more papers by this author
First published: 23 October 2012
Citations: 15

Abstract

Anisotropic surface topography is known to induce the contact guidance of cells, and facile and biocompatible approaches of the physical modification of the pertinent matrix surfaces are thus meaningful for biomaterials. Herein, we put forward a sugar-fiber imprinting technique to generate microgrooves on hydrophobic polymers demonstrated by the poly(lactic-co-glycolic acid) (PLGA) films. Microgrooves were conveniently generated after removing sugar fibers simply by water. The resulting locally anisotropic microgrooves were confirmed to elongate the cells cultured on the surface.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.