Pd-NHC-Catalyzed Direct Arylation of 1,4-Disubstituted 1,2,3-Triazoles with Aryl Halides
Tao He
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
Search for more papers by this authorMin Wang
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
Search for more papers by this authorPinhua Li
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
Search for more papers by this authorCorresponding Author
Lei Wang
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China, Tel.: 0086-0561-3802069; Fax: 0086-561-03090518Search for more papers by this authorTao He
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
Search for more papers by this authorMin Wang
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
Search for more papers by this authorPinhua Li
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
Search for more papers by this authorCorresponding Author
Lei Wang
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, China, Tel.: 0086-0561-3802069; Fax: 0086-561-03090518Search for more papers by this authorAbstract
A highly efficient method for the synthesis of unsymmetrical multi-substituted 1,2,3-triazoles via a direct Pd-NHC system catalyzed C(5)-arylation of 1,4-disubstituted triazoles, which are readily accessible via "click" chemistry has been developed. It is important to note that CH bond functionalizations of 1,2,3-triazoles with a variety of differently substituted aryl iodides and bromides as electrophiles can be conveniently achieved through this catalytic system at significantly milder reaction temperatures of 100°C under air.
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