Volume 26, Issue 2 pp. 363-367
Full Paper

Cascade Reaction and Synthesis of Bicyclo[2,2,2]octenones

Nian-Guang LI

Nian-Guang LI

Key Laboratory of Carcinogesis and Intervention of Jiangsu Province, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Department of Medicinal Chemistry, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210046, China

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Jin-Xin WANG

Jin-Xin WANG

Key Laboratory of Carcinogesis and Intervention of Jiangsu Province, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

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Qi-Dong YOU

Qi-Dong YOU

Key Laboratory of Carcinogesis and Intervention of Jiangsu Province, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Tel.: 0086-025-83271351; Fax: 0086-025-83271351

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Gang CHU

Gang CHU

Key Laboratory of Carcinogesis and Intervention of Jiangsu Province, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

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Qing-Long GUO

Qing-Long GUO

Key Laboratory of Carcinogesis and Intervention of Jiangsu Province, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

Department of Physiology, China Pharmaceutical University, Nanjing, Jiangsu 210009, China

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First published: 18 February 2008
Citations: 4

Abstract

During study on the remarkable cascade reaction for synthesis of compound 1, the neo-caged scaffold 2 with a heterocyclic bicyclo[2.2.2]octenone moiety and two new allyl substituted xanthones 3, 4 were obtained besides the known caged scaffold 1. The probable reaction processes were also elucidated in this paper.

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