Further Daphniphyllum Alkaloids from the Bark of Daphniphyllum macropodum Miq.
Zhen-Yu LI
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorPing CHEN
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorHong-Gui XU
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Search for more papers by this authorShu-Ying PENG
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorYi-Ming YANG
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorZhong-Zhen ZHAO
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Search for more papers by this authorZhen-Yu LI
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorPing CHEN
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorHong-Gui XU
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Search for more papers by this authorShu-Ying PENG
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorYi-Ming YANG
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Search for more papers by this authorZhong-Zhen ZHAO
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
Search for more papers by this authorAbstract
Four new Daphniphyllum alkaloids, namely dehydroxymacropodumine A (1), 4,21-deacetyl-23-demethyl-deoxyyuzurimine (2), 7-oxo-deoxyyuzurimine (3), and 4-acetoxydaphmanidin B (4), together with seven known related alkaloids, were isolated from the bark of Daphniphyllum macropodum Miq. The structures of new compounds 1–4 including relative configurations were elucidated on the basis of detailed spectroscopic data analysis and by comparison with related known compounds. Dehydroxymacropodumine A (1) possesses a rare eleven-membered macrolactone ring representing the second example of this backbone isolated from natural sources.
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