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Study of the Interaction of Cephalosporin Class Medicine with Albumin by Fluorescence Enhancement and Fluorescence Quenching Theories

Man-Man Yang

College of Chemistry and Chemical Engineering, Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, Taiyuan 030006, China

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Qin Xiao,

Qin Xiao

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Xiao-Li Xi,

Xiao-Li Xi

yangpin@sxu. edu. cn

Project supported by the National Natural Science Foundation of China (No. 30470408) and the Shanxi Provincial Natural Science Foundation.

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Man-Man Yang,

Man-Man Yang

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Qin Xiao,

Qin Xiao

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Xiao-Li Xi,

Xiao-Li Xi

yangpin@sxu. edu. cn

Project supported by the National Natural Science Foundation of China (No. 30470408) and the Shanxi Provincial Natural Science Foundation.

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First published: 16 May 2006

https://doi.org/10.1002/cjoc.200690123

Citations: 47

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Abstract

The interaction of 7 kinds of cephalosporin-medicine with HSA and BSA was studied and compared using fluorescence enhancement and fluorescence quenching method, then deeply analyzed. The binding characteristics of medicine with albumin and usual characteristic constants such as dissociation constant, quenching constant, quenching efficiency, energy-transfer efficiency and the distance between donor and accepter were also deeply analyzed.

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Volume24, Issue5

May, 2006

Pages 642-648

Study of the Interaction of Cephalosporin Class Medicine with Albumin by Fluorescence Enhancement and Fluorescence Quenching Theories

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Study of the Interaction of Cephalosporin Class Medicine with Albumin by Fluorescence Enhancement and Fluorescence Quenching Theories

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