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A novel reductive cyclization of o-nitrobenzamides and ketones promoted by low-valent titanium reagent
First published: 26 August 2010
Abstract
A short and facile synthesis of a series of 1, 2-dihydroquiazolin-4(3H)-ones was accomplished in good yields via novel reductive cyclization of o-nitrobenzamides with ketones promoted by TiCl4/Zn system. The structure was established on the basis of elemental analysis, IR, 'H NMR and confirmed by a single-crystal X-ray diffraction analysis. This method has the advantages of easily accessible starting materials, convenient manipulation and moderate to high yields.
