Volume 21, Issue 11 pp. 1497-1500

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Solid Phase Synthesis of Ethyl β-Substituted Indolepropionates

Zhan-Xiang Liu,

Zhan-Xiang Liu

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China

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Xiu-Xiu Ruan,

Xiu-Xiu Ruan

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China

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Xian Huang,

Xian Huang

[email protected]

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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Zhan-Xiang Liu,

Zhan-Xiang Liu

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China

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Xiu-Xiu Ruan,

Xiu-Xiu Ruan

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China

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Xian Huang,

Xian Huang

[email protected]

Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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First published: 26 August 2010

https://doi.org/10.1002/cjoc.20030211121

Citations: 2

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Abstract

A facile solid phase synthesis of ethyl β-substituted indolepropionates is reported. Condensation between indole, polymer-supported cyclic malonic acid ester and aldehyde yielded the trimolecular adducts, which was cleaved by pyridine/EtOH to release the final products in good yield with high purity.

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Volume21, Issue11

November 2003

Pages 1497-1500

Solid Phase Synthesis of Ethyl β-Substituted Indolepropionates

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Solid Phase Synthesis of Ethyl β-Substituted Indolepropionates

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