Volume 21, Issue 9 pp. 1238-1240
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Synthesis and photocleaving DNA activity of 4′-chlorobenzene-sulfonyl chloride-pyrrolecarboxamide hybrid compound

Fei-Li Tang

Fei-Li Tang

Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing 100871, China

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Gu Yuan

Gu Yuan

Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing 100871, China

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First published: 26 August 2010
Citations: 1

Abstract

A 4′-chlorobenzenesulfonyl chloride-pyrrolecarboxamide hybrid compound was synthesized and its DNA cleaving activity was investigated using a pBluescript SK DNA under UV irradiation. This compound showed potent DNA cleaving activity.

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