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Novel asymmetric total synthesis of (+)-6-epicastanospermine†
Hong-Xing Zhang,
Peng Xia,
Wei-Shan Zhou,
Hong-Xing Zhang
Department of Chemistry, Medical Center of Fudan University, Shanghai 200032, China
Search for more papers by this authorPeng Xia
Department of Medicinal Chemistry, Pharmacy School, Medical Center of Fudan University, Shanghai 200032, China
Search for more papers by this authorWei-Shan Zhou
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this authorHong-Xing Zhang,
Peng Xia,
Wei-Shan Zhou,
Hong-Xing Zhang
Department of Chemistry, Medical Center of Fudan University, Shanghai 200032, China
Search for more papers by this authorPeng Xia
Department of Medicinal Chemistry, Pharmacy School, Medical Center of Fudan University, Shanghai 200032, China
Search for more papers by this authorWei-Shan Zhou
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Search for more papers by this author†
Dedicated to Professor HUANG Wei-Yuan on the occasion of his 80th birthday.
Abstract
An asymmetric total synthesis of (+)-6-epicastanospermine was achieved in 13 steps and 19% overall yield from β-hydroxy-α-furfurylamine derivative, which was prepared by Sharpless asymmetric aminohydroxylation of furyl acrylate.
References
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