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Palladium(II)-catalyzed cyclization of W-(2′,4′-dienyl)-2-alkynamides to α-alkylidene-γ-butyrolactams^†

Xa He

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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H-Yan Lu,

H-Yan Lu

[email protected]

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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Guo-Sheng Liu,

Guo-Sheng Liu

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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Xa He,

Xa He

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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H-Yan Lu,

H-Yan Lu

[email protected]

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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Guo-Sheng Liu,

Guo-Sheng Liu

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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First published: 26 August 2010

https://doi.org/10.1002/cjoc.20010191221

Citations: 1

^†

Dedicated to Professor HUANG Wei-Yuan on the occasion of his 80th birthday.

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Abstract

In the presence of CuCl₂, N-(2′, 4′-dienyl)-2-alkynamides can be converted to α-alkylidene-σ-butyrolactams under the catalysis of palladium(II). In this reaction, CuCl₂ is used to oxidize Pd(0) to regenerate Pd(II), or the carbon-palladium bond is quenched by the oxidative cleavage reaction of CuCl₂.

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Volume19, Issue12

December 2001

Pages 1285-1288

Palladium(II)-catalyzed cyclization of W-(2′,4′-dienyl)-2-alkynamides to α-alkylidene-γ-butyrolactams^†

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Palladium(II)-catalyzed cyclization of W-(2′,4′-dienyl)-2-alkynamides to α-alkylidene-γ-butyrolactams†

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Palladium(II)-catalyzed cyclization of W-(2′,4′-dienyl)-2-alkynamides to α-alkylidene-γ-butyrolactams^†