Low-valent Titanium Induced Reductive Coupling of O-Nitrophenylazide with Benzoyl Substituted Ketene Dithioacetals: a Novel Synthesis of 4-Aryl-2-methylthio-3Z7-l,5-benzodiazepines

Zhi-Fang Li,

Zhi-Fang Li

[email protected]

Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, Zhejiang 310028, China

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Yong-Min Zhang,

Yong-Min Zhang

Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, Zhejiang 310028, China

State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

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Zhi-Fang Li,

Zhi-Fang Li

[email protected]

Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, Zhejiang 310028, China

Search for more papers by this author

Yong-Min Zhang,

Yong-Min Zhang

Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou, Zhejiang 310028, China

State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Search for more papers by this author

First published: 26 August 2010

https://doi.org/10.1002/cjoc.20010191016

Citations: 5

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Abstract

Treated with the low-valent titanium derived from TiCl₄/Sm system, o-nitrophenylazide could produce the intermediate 2 in situ, which reacted with benzoyl substituted ketene dithioacetals to afford 4-aryl-2-methylthio-3H-1,5-benzodiazepines in good yields under mild and neutral conditions.

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Volume19, Issue10

October 2001

Pages 996-998

Low-valent Titanium Induced Reductive Coupling of O-Nitrophenylazide with Benzoyl Substituted Ketene Dithioacetals: a Novel Synthesis of 4-Aryl-2-methylthio-3Z7-l,5-benzodiazepines

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Low-valent Titanium Induced Reductive Coupling of O-Nitrophenylazide with Benzoyl Substituted Ketene Dithioacetals: a Novel Synthesis of 4-Aryl-2-methylthio-3Z7-l,5-benzodiazepines

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