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Synthesis, Relaxivity and MRI Enhancement of Linear Oligo-Gd(III) Complexes with Poly (DTPA-ester) Ligands Derived from Amino Acids
Abstract
Six linear oligo-DTPA-ester Gd(III) complexes being used for potential MRI contrast agents were synthesized from amino adds and characterized. Their longitudinal relaxation rates were measured. One of them, die phenylalanine derivative, with high relaxivity, was chosen for the acute toxicity and T1,-weighted imaging test. The results indicated that there was no obvious toxicity for this new oligomeric Gd(III) complex, and it exhibits the highly enhanced MRI signal intensity and the increasing signal duration in the liver tissue compared to Gd-DTPA.
